Aortic aneurysm is observed as a result of the extensive alteration in the elasticity of the aortic wall due to the breakdown of elastin and collagen. In this study, we studied the feasibility of scanning acoustic microscopy (SAM) and Raman spectroscopy (RS) in characterizing the dilated segments of the aorta from male and female patients with aortic aneurysm. SAM determined the acoustic property variation in the aorta by calculating the acoustic impedance values of aorta samples of 18 patients. RS determined the disease states by analyzing the chemical variation especially in the peaks related to elastin and collagen using the k-means classification method. Consequently, we assume that combining these two techniques in clinics will help to investigate the dilated segment of the aorta with micrometer resolution, which will reduce the possibility of new aneurysm formation due to a segment not excised during the surgery.

中文翻译：

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通过扫描声学显微镜和拉曼光谱评估主动脉瘤

由于弹性蛋白和胶原蛋白的分解，主动脉壁的弹性发生了广泛的改变，因此观察到主动脉瘤。在这项研究中，我们研究了扫描声学显微镜 (SAM) 和拉曼光谱 (RS) 在表征男性和女性主动脉瘤患者的主动脉扩张段的可行性。SAM 通过计算 18 名患者的主动脉样本的声阻抗值来确定主动脉中的声学特性变化。RS 通过分析化学变化来确定疾病状态，尤其是在与弹性蛋白和胶原蛋白相关的峰中使用k-表示分类方法。因此，我们假设在临床中结合这两种技术将有助于以微米分辨率研究扩张的主动脉段，这将减少由于手术期间未切除的段而形成新动脉瘤的可能性。