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Technological perspectives on laser speckle micro-rheology for cancer mechanobiology research
Journal of Biomedical Optics ( IF 3.5 ) Pub Date : 2021-09-01 , DOI: 10.1117/1.jbo.26.9.090601
Zeinab Hajjarian 1 , Seemantini K Nadkarni 1
Affiliation  

Significance: The ability to measure the micro-mechanical properties of biological tissues and biomaterials is crucial for numerous fields of cancer research, including tumor mechanobiology, tumor-targeting drug delivery, and therapeutic development. Aim: Our goal is to provide a renewed perspective on the mainstream techniques used for micro-mechanical evaluation of biological tissues and biomimetic scaffoldings. We specifically focus on portraying the outlook of laser speckle micro-rheology (LSM), a technology that quantifies the mechanical properties of biomaterials and tissues in a rapid, non-contact manner. Approach: First, we briefly explain the motivation and significance of evaluating the tissue micro-mechanics in various fields of basic and translational cancer research and introduce the key concepts and quantitative metrics used to explain the mechanical properties of tissue. This is followed by reviewing the general active and passive themes of measuring micro-mechanics. Next, we focus on LSM and elaborate on the theoretical grounds and working principles of this technique. Then, the perspective for measuring the micro-mechanical properties via LSM is outlined. Finally, we draw an overview picture of LSM in cancer mechanobiology research. Results: With the continued emergence of new approaches for measuring the mechanical attributes of biological tissues, the field of micro-mechanical imaging is at its boom. As one of these competent innovations, LSM presents a tremendous potential for both technical maturation and prospective applications in cancer biomechanics and mechanobiology research. Conclusion: By elaborating the current viewpoint of LSM, we expect to accelerate the expansion of this approach to new territories in both technological domains and applied fields. This renewed perspective on LSM may also serve as a road map for other micro-mechanical measurement concepts to be applied for answering mechanobiological questions.

中文翻译:

激光散斑微流变学在癌症力学生物学研究中的技术前景

意义:测量生物组织和生物材料的微观力学特性的能力对于癌症研究的众多领域至关重要,包括肿瘤力学生物学、肿瘤靶向药物递送和治疗开发。目标:我们的目标是为用于生物组织和仿生支架微机械评估的主流技术提供新的视角。我们特别关注描绘激光散斑微流变学 (LSM) 的前景,这是一种以快速、非接触方式量化生物材料和组织的机械性能的技术。方法:首先,我们简要解释了在基础和转化癌症研究的各个领域中评估组织微观力学的动机和意义,并介绍了用于解释组织力学特性的关键概念和定量指标。然后回顾测量微观力学的一般主动和被动主题。接下来,我们专注于 LSM 并详细阐述该技术的理论基础和工作原理。然后,概述了通过 LSM 测量微机械性能的前景。最后,我们绘制了癌症力学生物学研究中 LSM 的概述图。结果:随着测量生物组织机械属性的新方法不断出现,微机械成像领域正处于蓬勃发展阶段。作为这些有能力的创新之一,LSM 在癌症生物力学和力学生物学研究中的技术成熟和前瞻性应用方面具有巨大的潜力。结论:通过阐述 LSM 的当前观点,我们希望将这种方法加速扩展到技术领域和应用领域的新领域。这种对 LSM 的新观点也可以作为其他微机械测量概念的路线图,用于回答机械生物学问题。
更新日期:2021-09-22
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