The plant-derived polyphenol tannic acid (TA) was used to crosslink linear statistical polymers containing benzoxaborole [poly(MPC-st-MAABO)] to form a bio-inspired, multi-responsive, injectable, and self-healing hydrogel in the physiological environment via benzoxaborole–tannic acid complexation. The mechanical properties of the hydrogel were easily tuned by adjusting the molar ratio between tannic acid and benzoxaborole groups. Fast degradation of the hydrogel was observed in the presence of fructose, adenosine 5′-triphosphate (ATP), and dopamine (catechol), and reversible sol–gel formation was induced by changing the pH of the hydrogel. As the hydrogel was crosslinked by dynamic boronic ester bonds, the self-healing property and injectability were expected and confirmed. 3D cell encapsulation within the hydrogel scaffold was successfully achieved. This technique offered a promising method for preparing bio-inspired, multi-responsive, injectable, and self-healing hydrogels to fulfill current demands in biomedical applications.

中文翻译：

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基于苯并恶唑-单宁酸络合的多响应、可注射和自修复水凝胶

植物来源的多酚单宁酸 (TA) 用于交联含有苯并恶唑 [poly( MPC- st -MAABO)] 的线性统计聚合物，在生理学中形成仿生、多响应、可注射和自愈的水凝胶。环境通过苯并恶唑-单宁酸络合。通过调节单宁酸和苯并恶唑基团之间的摩尔比，可以轻松调节水凝胶的机械性能。在果糖、5'-三磷酸腺苷 (ATP) 和多巴胺 (儿茶酚) 存在下观察到水凝胶的快速降解，并且通过改变水凝胶的 pH 值诱导可逆的溶胶-凝胶形成。由于水凝胶是通过动态硼酸酯键交联的，因此预期并证实了自愈性能和可注射性。成功实现了水凝胶支架内的 3D 细胞封装。该技术为制备仿生、多响应、可注射和自修复水凝胶提供了一种很有前景的方法，以满足当前生物医学应用的需求。