Integrating multi-modal imaging and therapy functions into a nanoplatform has been recognized as a promising strategy for cancer theranostics with high accuracy and efficiency. However, there are still some challenges, such as the complicated synthesis process and instability. Herein, we successfully prepared clearable MnCo₂O₄ nanodots modified with polyacrylic acid (MnCo₂O₄@PAA) as nanoagents for T₁/T₂ bimodal MRI imaging-guided PTT. Owing to their intrinsic magnetic properties, single MnCo₂O₄@PAA nanomaterials can serve as contrasts for T₁/T₂ bimodal MRI, providing precise diagnotic information. Moreover, excellent absorption in the NIR biowindow endows MnCo₂O₄@PAA with good photothermal performance, and the ultrasmall size of MnCo₂O₄@PAA allows them to penetrate deeply into tumors, resulting in a good anticancer effect in vitro and in vivo. What is more, MnCo₂O₄@PAA can almost be completely cleared from mice at 7 d postinjection, implying their negligible long-term toxicity. These findings demonstrate that MnCo₂O₄@PAA are promising nanoagents for cancer diagnosis and treatment, which have great potential for clinical applications.

中文翻译：

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可快速清除的 MnCo2O4@PAA 作为用于 T1/T2 双峰 MRI 成像引导光热疗法的新型纳米治疗剂

将多模态成像和治疗功能集成到纳米平台中已被公认为具有高精度和效率的癌症治疗学的有前途的策略。然而，仍然存在一些挑战，例如复杂的合成过程和不稳定性。在此，我们成功制备了聚丙烯酸改性的可清除 MnCo ₂ O ₄纳米点（MnCo ₂ O ₄ @PAA）作为 T ₁ /T ₂双峰 MRI 成像引导 PTT 的纳米剂。由于其固有的磁性，单一的 MnCo ₂ O ₄ @PAA 纳米材料可以作为 T ₁ /T _{2 的}对比双模态 MRI，提供精确的诊断信息。此外，在近红外生物窗口中出色的吸收使MnCo ₂ O ₄ @PAA 具有良好的光热性能，并且MnCo ₂ O ₄ @PAA的超小尺寸使其能够深入渗透到肿瘤中，从而在体外和体内产生良好的抗癌效果. 更重要的是，MnCo ₂ O ₄ @PAA 在注射后 7 天几乎可以从小鼠中完全清除，这意味着它们的长期毒性可以忽略不计。这些发现表明 MnCo ₂ O ₄@PAA 是用于癌症诊断和治疗的有前途的纳米药物，具有巨大的临床应用潜力。