Abstract: Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent single-gene disorder leading to renal failure. Current therapies are aimed to treat renal and extrarenal complications of ADPKD, but improved knowledge of the pathophysiological mechanisms leading to the generation and growth of cysts has permitted the identification of new drug candidates for clinical trials. Among these, in this review, we will examine above all the role of metformin, hypothesized to be able to activate the AMP-activated protein kinase (AMPK) pathway and potentially modulate some mechanisms implicated in the onset and the growth of the cysts.

Keywords: cystogenesis, renal cells, metformin, chronic renal disease, renal tubule


中文翻译：

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使用二甲双胍和其他疗法延缓常染色体显性多囊肾病慢性肾脏病的进展：新见解的更新

摘要：常染色体显性多囊肾病（ADPKD）是导致肾功能衰竭最常见的单基因疾病。目前的疗法旨在治疗 ADPKD 的肾脏和肾外并发症，但对导致囊肿产生和生长的病理生理机制的认识的提高已经允许鉴定用于临床试验的新候选药物。其中，在本综述中，我们将首先检查二甲双胍的作用，假设二甲双胍能够激活 AMP 活化蛋白激酶 (AMPK) 途径并可能调节一些与囊肿发病和生长有关的机制。

关键词：囊肿发生，肾细胞，二甲双胍，慢性肾病，肾小管