Since the pathogenic bacteria biofilms are involved in 70% of chronic infections and their resistance to antibiotics is increased, the research in this field requires new healing agents.

New composite hydrogels were designed as potential chronic wound dressings composed of bacterial cellulose (BC) with chitosan polymer (Chi) – BC-Chi and chitosan nanoparticles (nChiD) – BC-nChiD. nChiD were obtained by gamma irradiation at doses: 20, 40 and 60 kGy. Physical and chemical analyses showed incorporation of Chi and encapsulation of nChiD into BC. The BC-Chi has the highest average surface roughness. BC-nChiD hydrogels show an irradiated dose-dependent increase of average surface roughness. New composite hydrogels are biocompatible with excellent anti-biofilm potential with up to 90% reduction of viable biofilm and up to 65% reduction of biofilm height. The BC-nChiD showed better dressing characteristics: higher porosity, higher wound fluid absorption and faster migration of cells (in vitro healing). All obtained results confirmed both composite hydrogels as promising chronic wound healing agents.

由于70%的慢性感染涉及病原菌生物膜，并且它们对抗生素的耐药性增加，因此该领域的研究需要新的愈合剂。

新型复合水凝胶被设计为潜在的慢性伤口敷料，由细菌纤维素 (BC) 与壳聚糖聚合物 (Chi) – BC-Chi 和壳聚糖纳米颗粒 (nChiD) – BC-nChiD 组成。nChiD 是通过伽马辐射获得的，剂量为：20、40 和 60 kGy。物理和化学分析表明 Chi 掺入和 nChiD 封装到 BC 中。BC-Chi 具有最高的平均表面粗糙度。BC-nChiD 水凝胶显示平均表面粗糙度的辐照剂量依赖性增加。新型复合水凝胶具有生物相容性，具有出色的抗生物膜潜力，可减少高达 90% 的活生物膜，减少高达 65% 的生物膜高度。BC-nChiD 显示出更好的敷料特性：更高的孔隙率、更高的伤口液体吸收和更快的细胞迁移（体外康复）。所有获得的结果都证实了两种复合水凝胶都是有前途的慢性伤口愈合剂。