The Rh(III)-catalyzed reaction of aniline derivatives that contain a pyrimidine directing group with vinylsilanes results in the formation of C3-substituted indoline derivatives in a highly regioselective manner via a C–H activation/alkene cyclization cascade. The results of the mechanistic experiments indicate that C–H bond cleavage is not the rate-determining step and that the reaction proceeds via the formation of a six-membered rhodacycle as a key catalytic species through a pyrimidine-directed electrophilic ortho-C–H rhodation.

中文翻译：

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Rh(III)-催化的 [3 + 2] 苯胺衍生物与乙烯基硅烷通过 C–H 活化/烯烃环化的环化：获得高度区域选择性的二氢吲哚衍生物

含有嘧啶导向基团的苯胺衍生物在 Rh(III) 催化下与乙烯基硅烷反应，通过C-H 活化/烯烃环化级联反应以高度区域选择性的方式形成 C3 取代的二氢吲哚衍生物。机理实验的结果表明，C-H 键断裂不是速率决定步骤，反应通过形成六元红环作为关键催化物种通过嘧啶定向的亲电邻-C-H 进行。罗丹宁。