An intermolecular enantioselective synthesis of 1H-isoindoles containing tri- and difluoromethylated quaternary stereogenic centers through a palladium-catalyzed desymmetric C–H bond imidoylation has been developed. α,α-Diaryl tri- and difluoroethylated isocyanides acted as powerful precursors of chiral 1H-isoindoles, in which the fluoroalkyl group was proven to play a crucial role in both the stereochemistry and reaction efficiency. In addition, an allene insertion cascade was realized, offering rapid access to diverse C1-tethered bis-heterocyclic scaffolds with good yields and high enantioselectivities. The reactions proceeded smoothly under mild conditions with low catalyst loadings.

中文翻译：

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通过钯催化的 C-H 键亚胺酰化对含有三和二氟甲基化四元立体中心的 1H-异吲哚进行对映选择性构建

已经开发了一种通过钯催化的去对称 C-H 键亚胺酰化作用合成含有三和二氟甲基化季立体中心的 1 H-异吲哚的分子间对映选择性合成。α,α-二芳基三和二氟乙基化异氰化物是手性 1 H-异吲哚的强大前体，其中氟烷基被证明在立体化学和反应效率中都起着至关重要的作用。此外，实现了丙二烯插入级联，可快速获得具有良好产率和高对映选择性的各种 C1 系链双杂环支架。反应在温和条件下顺利进行，催化剂负载量低。