当前位置: X-MOL 学术J. Biomed. Nanotechnol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Graphene Oxide Nanosheets with Efficient Antibacterial Activity Against Methicillin-Resistant Staphylococcus aureus (MRSA).
Journal of Biomedical Nanotechnology ( IF 2.9 ) Pub Date : 2021-9-22 , DOI: 10.1166/jbn.2021.3123
Yujie Gao 1 , Yuanhao Dong 1 , Yubin Cao 1 , Wenlong Huang 1 , Chenhao Yu 1 , Shangyan Sui 1 , Anchun Mo 2 , Qiang Peng 1
Affiliation  

The development of drug-resistant bacteria has become a public health problem, among which methicillin-resistant Staphylococcus aureus (MRSA) leads to various life-threatening diseases. Graphene oxide (GO) is a two-dimensional nanomaterial with potential in the anti-MRSA treatment. This study prepared GO nanosheets with fixed lamellar size, investigated its antibacterial activity against MRSA, and analyzed the related antibacterial mechanisms. We found that the fabrication of GO with stable dispersion was workable. Furthermore, such GO had superior antibacterial performance against MRSA at low concentrations with the dose-dependent anti-MRSA effect. The GO-MRSA interaction also provided fundamental support for the antibacterial mechanisms with cleavage and encapsulation effects. In conclusion, GO nanosheets may be a promising antimicrobial agent against MRSA.

中文翻译:

对耐甲氧西林金黄色葡萄球菌 (MRSA) 具有高效抗菌活性的氧化石墨烯纳米片。

耐药菌的发展已成为公共卫生问题,其中耐甲氧西林金黄色葡萄球菌(MRSA) 导致各种危及生命的疾病。氧化石墨烯 (GO) 是一种二维纳米材料,具有抗 MRSA 治疗的潜力。本研究制备了具有固定层状尺寸的 GO 纳米片,研究了其对 MRSA 的抗菌活性,并分析了相关的抗菌机制。我们发现制备具有稳定分散性的 GO 是可行的。此外,这种GO在低浓度下对MRSA具有优异的抗菌性能,具有剂量依赖性的抗MRSA效应。GO-MRSA 相互作用也为具有裂解和封装作用的抗菌机制提供了基本支持。总之,GO纳米片可能是一种有前途的抗MRSA抗菌剂。
更新日期:2021-09-22
down
wechat
bug