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Multifunctional Biomedical Applications of Nitrogen and Sulfur Co-Doped Carbon Dots.
Journal of Biomedical Nanotechnology ( IF 2.9 ) Pub Date : 2021-9-22 , DOI: 10.1166/jbn.2021.3131
Dan Zhao 1 , Rui Zhang 1 , Mengyu Xu 1 , Xincai Xiao 1 , Haiyan Zhao 1 , Xianju Huang 1
Affiliation  

Multifunctional carbon dots have drawn considerable attention due to their potential biomedical application value. We report the preparation of blue-green fluorescence-emitting, multifunctional, nitrogen-and-sulfur co-doped carbon dots (N, S-CDs) synthesized via a one-step process using 1-thioglycerol as a sulfur source, glucose and citric acid as carbon sources, and polyethyleneimine as a nitrogen source. Because of abundant amino and sulfur content, the CDs exhibited high sensibility and selectivity for detecting Cu2+ (detection limit: 0.01 μM, linear range: 0.025 to 50 μM). Fast and sensitive detection of tiopronin was also achieved on the basis of the fluorescence "off-on" mode considering the strong affinity between tiopronin and Cu2+. The N, S-CDs exhibited good biocompatibility as determined by fluorescence imaging using onion epidermal cells and gram-positive bacteria. The CDs also exhibited excellent antimicrobial ability against the gram-positive bacteria. Our results indicate that these novel N, S-CDs could be ideal candidates for several biochemical applications such as antibacterial treatment and detection of small biomolecules.

中文翻译:

氮硫共掺杂碳点的多功能生物医学应用。

多功能碳点因其潜在的生物医学应用价值而备受关注。我们报告了使用 1-硫代甘油作为硫源、葡萄糖和柠檬酸的一步法合成的蓝绿色荧光发射、多功能、氮和硫共掺杂碳点(N、S-CD)的制备。酸为碳源,聚乙烯亚胺为氮源。由于丰富的氨基和硫含量,CDs对Cu 2+ 的检测表现出很高的灵敏度和选择性(检测限:0.01 μM,线性范围:0.025至50 μM)。考虑到硫普罗宁与Cu 2+之间的强亲和力,基于荧光“关-开”模式,也实现了硫普罗宁的快速灵敏检测. N, S-CDs 表现出良好的生物相容性,如使用洋葱表皮细胞和革兰氏阳性菌通过荧光成像确定的。CDs 还对革兰氏阳性菌表现出优异的抗菌能力。我们的结果表明,这些新型 N, S-CD 可能是多种生化应用的理想候选者,例如抗菌治疗和小生物分子检测。
更新日期:2021-09-22
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