Effective monitoring of pesticide residues in food and environmental samples is of high importance as these chemical residues undergo ongoing eco- and bio-accumulation, compromising the health of humans and animals alike. Several sensor platforms are being developed for the detection of pesticide residues in a range of sample matrices. A relatively new sensor platform that has gained enormous attention is based on the natural enzyme-mimicking catalytic activity of nanomaterials, more commonly referred to as nanozyme activity. In this review, we provide a critical overview of the recent advances in nanozyme-based sensing strategies for the detection of pesticides. The review highlights the salient features and the working principle of various nanozyme-based sensors, their integration with molecular recognition elements (MREs) to improve target specificity, and associated limitations that must be overcome to turn nanozyme sensors into mainstream analytical tools. The review further provides a critical outlook of nanozyme-based sensors for pesticide detection. The last section of the review outlines the steps that must be taken to realise the full potential of nanozyme-based sensors.

有效监测食品和环境样品中的农药残留非常重要，因为这些化学残留物会持续进行生态和生物积累，危害人类和动物的健康。目前正在开发多种传感器平台，用于检测一系列样品基质中的农药残留。一种获得极大关注的相对较新的传感器平台基于纳米材料的天然酶模拟催化活性，通常称为纳米酶活性。在这篇综述中，我们对基于纳米酶的农药检测传感策略的最新进展进行了重要概述。该评论突出了各种基于纳米酶的传感器的显着特征和工作原理，它们与分子识别元件 (MRE) 的整合以提高目标特异性，以及将纳米酶传感器转变为主流分析工具必须克服的相关限制。该评论进一步提供了基于纳米酶的农药检测传感器的重要前景。评论的最后一部分概述了实现基于纳米酶的传感器的全部潜力必须采取的步骤。