Introduction: We explored the cross-reactivity among 19 common allergen sources and evaluated the influence of serum IgE concentrations and the number of sensitized allergens on the incidence of allergic symptoms. Methods: We conducted this cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) 2005–2006 which is a program of studies designed to assess the health and nutritional status of adults and children in the USA. After excluding participants with missing data from the allergen IgE test, allergy questionnaire, and respiratory health questionnaire, a total of 7,224 participants aged 6 years and older were included, as children younger than 6 years old did not complete all 19 allergen-specific IgE tests. Spearman correlation analysis was used to analyze the cross-reactivity between allergen sources. An independent sample Kruskal-Wallis test was performed to investigate the relationship between the serum-specific IgE levels of 19 allergens and the incidence of allergic symptoms. Results: The cross-reactivity between D. farinae and D. pteronyssinus was the strongest (ρ = 0.88), and cross-reactivity of cross-species was universal. With the increase in serum-specific IgE levels of D. farinae, D. pteronyssinus, oak, and birch, the incidence of sneezing increased (p #x3c; 0.05). With the increase in serum-specific IgE levels of cats, dogs, peanuts, Aspergillus, and Alternaria, the incidence of wheezing increased (p #x3c; 0.05). The incidence of rash was positively correlated with serum-specific IgE levels of D. farinae, D. pteronyssinus, shrimp, and peanut (p #x3c; 0.05). The incidence of wheezing continued to increase with an increase in sensitized allergens. When participants were sensitized to #x3c;10 allergens, the incidence of sneezing continued to increase as the number of sensitized allergens increased, whereas the incidence of rash did not have a clear association with the number of sensitized allergens. Conclusion: Species that are biologically close are more likely to have antigen cross-reactivity, while cross-reactivity among different species is common. Different allergens tend to cause different allergic symptoms. Different allergic sites in the body have inconsistent responses to the number of sensitized allergens.
Int Arch Allergy Immunol

中文翻译：

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19 种过敏原的交叉反应和过敏症状分析：NHANES 2005-2006 的结果

简介：我们探讨了 19 种常见过敏原来源之间的交叉反应性，并评估了血清 IgE 浓度和致敏过敏原数量对过敏症状发生率的影响。方法：我们使用来自 2005-2006 年国家健康和营养检查调查 (NHANES) 的数据进行了这项横断面分析，该调查是一项旨在评估美国成人和儿童健康和营养状况的研究计划。剔除过敏原 IgE 检测、过敏问卷和呼吸系统健康问卷缺失数据的参与者后，共有 7,224 名 6 岁及以上的参与者被纳入，因为 6 岁以下的儿童未完成所有 19 项过敏原特异性 IgE 检测. Spearman相关分析用于分析过敏原来源之间的交叉反应性。进行了独立样本 Kruskal-Wallis 检验，以研究 19 种过敏原的血清特异性 IgE 水平与过敏症状发生率之间的关系。结果：D. farinae和D. pteronyssinus的交叉反应最强（ρ = 0.88），跨物种的交叉反应具有普遍性。随着粉尘螨、屋尘螨、橡树和桦树血清特异性IgE水平的增加，打喷嚏的发生率增加（ p # x3c；0.05）。随着猫、狗、花生、曲霉和链格孢菌血清特异性IgE水平的增加，喘息的发生率增加（p #x3c；0.05）。皮疹的发生率与粉尘螨、尘螨、虾和花生的血清特异性 IgE 水平呈正相关。p #x3c; 0.05)。随着致敏过敏原的增加，喘息的发生率继续增加。当参与者对#x3c;10 过敏原致敏时，随着致敏过敏原数量的增加，打喷嚏的发生率继续增加，而皮疹的发生率与致敏过敏原的数量没有明确的关联。结论：生物学上接近的物种更容易发生抗原交叉反应，而不同物种之间的交叉反应较为普遍。不同的过敏原往往会引起不同的过敏症状。体内不同的过敏部位对致敏过敏原的数量有不一致的反应。
Int Arch 过敏免疫