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Multifunctional Nanofibrous Dressing with Antimicrobial and Anti-Inflammatory Properties Prepared by Needle-Free Electrospinning
Pharmaceutics ( IF 5.4 ) Pub Date : 2021-09-21 , DOI: 10.3390/pharmaceutics13091527
Laura Victoria Schulte-Werning 1 , Anjanah Murugaiah 1 , Bhupender Singh 2 , Mona Johannessen 2 , Rolf Einar Engstad 3 , Nataša Škalko-Basnet 1 , Ann Mari Holsæter 1
Affiliation  

An active wound dressing should address the main goals in wound treatment, which are improved wound healing and reduced infection rates. We developed novel multifunctional nanofibrous wound dressings with three active ingredients: chloramphenicol (CAM), beta-glucan (βG) and chitosan (CHI), of which βG and CHI are active nanofiber-forming biopolymers isolated from the cell walls of Saccharomyces cerevisiae and from shrimp shells, respectively. To evaluate the effect of each active ingredient on the nanofibers' morphological features and bioactivity, nanofibers with both βG and CHI, only βG, only CHI and only copolymers, polyethylene oxide (PEO) and hydroxypropylmethylcellulose (HPMC) were fabricated. All four nanofiber formulations were also prepared with 1% CAM. The needle-free NanospiderTM technique allowed for the successful production of defect-free nanofibers containing all three active ingredients. The CAM-containing nanofibers had a burst CAM-release and a high absorption capacity. Nanofibers with all active ingredients (βG, CHI and CAM) showed a concentration-dependent anti-inflammatory activity, while maintaining the antimicrobial activity of CAM. The promising anti-inflammatory properties, together with the high absorption capacity and antimicrobial effect, make these multifunctional nanofibers promising as dressings in local treatment of infected and exuding wounds, such as burn wounds.

中文翻译:

无针静电纺丝制备抗菌抗炎多功能纳米纤维敷料

积极的伤口敷料应解决伤口治疗的主要目标,即改善伤口愈合和降低感染率。我们开发了新型多功能纳米纤维伤口敷料,含有三种活性成分:氯霉素(CAM)、β-葡聚糖(βG)和壳聚糖(CHI),其中βG和CHI是从酿酒酵母细胞壁中分离出来的活性纳米纤维形成生物聚合物。分别是虾壳。为了评估每种活性成分对纳米纤维形态特征和生物活性的影响,制备了同时含有βG和CHI、仅βG、仅CHI和仅共聚物、聚环氧乙烷(PEO)和羟丙基甲基纤维素(HPMC)的纳米纤维。所有四种纳米纤维配方均采用 1% CAM 制备。无针 Nanospider TM技术可以成功生产含有所有三种活性成分的无缺陷纳米纤维。含 CAM 的纳米纤维具有突发的 CAM 释放和高吸收能力。含有所有活性成分(βG、CHI 和 CAM)的纳米纤维均表现出浓度依赖性抗炎活性,同时保持了 CAM 的抗菌活性。具有前景的抗炎特性,加上高吸收能力和抗菌作用,使这些多功能纳米纤维有望作为敷料用于局部治疗感染和渗出伤口(例如烧伤伤口)。
更新日期:2021-09-21
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