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Changes in Affective Behavior and Oxidative Stress after Binge Alcohol in Male and Female Rats
Brain Sciences ( IF 3.3 ) Pub Date : 2021-09-21 , DOI: 10.3390/brainsci11091250
Ibanelo Cortez 1 , Patricia S Brocardo 2 , J Leigh Leasure 1, 3
Affiliation  

Binge alcohol consumption and alcohol use disorders (AUD) are prevalent, and there is comorbidity with depression and anxiety. Potential underlying mechanisms include neurophysiological, genetic, and metabolic changes resulting from alcohol exposure. Mood and anxiety disorders are more common among women, but whether females are more susceptible to binge-induced oxidative stress and co-occurring anxiety and depression-like behaviors remains unknown. Here, we used a repeated, weekly binge alcohol paradigm in male and female rats to investigate sex differences in despair and anxiety-like behaviors and brain oxidative stress parameters. A single binge alcohol exposure significantly elevated glutathione (GSH) levels in prefrontal cortex (PFC) of both male and female animals. This was accompanied by increased lipid peroxidation in PFC of both sexes. Repeated (once weekly) binge exposure induced changes in anxiety- and depression-like behaviors in both males and females and increased GSH level in the PFC without detectable oxidative damage. Our findings suggest that repeated binge alcohol exposure influences affect regardless of sex and in the absence of membrane damage.

中文翻译:

雄性和雌性大鼠酗酒后情感行为和氧化应激的变化

酗酒和酒精使用障碍 (AUD) 很普遍,并伴有抑郁和焦虑。潜在的潜在机制包括酒精暴露导致的神经生理学、遗传和代谢变化。情绪和焦虑症在女性中更为常见,但女性是否更容易受到暴食引起的氧化应激以及同时发生的焦虑和抑郁样行为的影响仍然未知。在这里,我们在雄性和雌性大鼠中使用重复的每周酗酒范式来研究绝望和焦虑样行为以及大脑氧化应激参数的性别差异。一次暴饮暴食会显着提高雄性和雌性动物前额叶皮层 (PFC) 中的谷胱甘肽 (GSH) 水平。这伴随着两性 PFC 中脂质过氧化的增加。重复(每周一次)暴饮暴食会导致男性和女性的焦虑和抑郁样行为发生变化,并增加 PFC 中的 GSH 水平,而没有可检测到的氧化损伤。我们的研究结果表明,无论性别如何,在没有膜损伤的情况下,反复暴饮暴食都会影响影响。
更新日期:2021-09-21
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