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Addiction and the cerebellum with a focus on actions of opioid receptors
Neuroscience & Biobehavioral Reviews ( IF 8.2 ) Pub Date : 2021-09-20 , DOI: 10.1016/j.neubiorev.2021.09.021
Hoda Ranjbar 1 , Monavareh Soti 1 , Mohammad Banazadeh 2 , Kiarash Saleki 3 , Kristi A Kohlmeier 4 , Mohammad Shabani 1
Affiliation  

Increasing evidence suggests that the cerebellum could play a role in the higher cognitive processes involved in addiction as the cerebellum contains anatomical and functional pathways to circuitry controlling motivation and saliency. In addition, the cerebellum exhibits a widespread presence of receptors, including opioid receptors which are known to play a prominent role in synaptic and circuit mechanisms of plasticity associated with drug use and development of addiction to opioids and other drugs of abuse. Further, the presence of perineural nets (PNNs) in the cerebellum which contain proteins known to alter synaptic plasticity could contribute to addiction. The role the cerebellum plays in processes of addiction is likely complex, and could depend on the particular drug of abuse, the pattern of use, and the stage of the user within the addiction cycle. In this review, we discuss functional and structural modifications shown to be produced in the cerebellum by opioids that exhibit dependency-inducing properties which provide support for the conclusion that the cerebellum plays a role in addiction.



中文翻译:

成瘾和小脑,重点是阿片受体的作用

越来越多的证据表明,小脑可能在涉及成瘾的高级认知过程中发挥作用,因为小脑包含控制动机和显着性的电路的解剖和功能途径。此外,小脑表现出广泛存在的受体,包括已知在与药物使用和对阿片类药物和其他滥用药物成瘾的发展相关的可塑性的突触和回路机制中发挥突出作用的阿片受体。此外,小脑中含有已知会改变突触可塑性的蛋白质的神经周围网络 (PNN) 的存在可能导致成瘾。小脑在成瘾过程中所起的作用可能很复杂,可能取决于滥用的特定药物、使用模式、以及用户在成瘾周期内的阶段。在这篇综述中,我们讨论了显示依赖诱导特性的阿片类药物在小脑中产生的功能和结构修饰,这为小脑在成瘾中起作用的结论提供了支持。

更新日期:2021-09-27
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