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NLRP3 inflammasome: A joint, potential therapeutic target in management of COVID-19 and fertility problems
Journal of Reproductive Immunology ( IF 3.4 ) Pub Date : 2021-09-21 , DOI: 10.1016/j.jri.2021.103427
Mahshid Bazrafkan 1 , Elham Hosseini 2 , Mahboobeh Nazari 3 , Christiani Andrade Amorim 4 , Mohammad Reza Sadeghi 1
Affiliation  

To overcome COVID-19 long-term consequences, one possible approach is to control inflammasomes activation, because SARS-CoV-2 can induce humoral and cellular immune responses. In this opinion article we hypothesized that if it is proven with convincing and unmistakable evidence that firstly, SARS-CoV-2 can enter cells and damage them through its common receptors in the reproductive tissues, and secondly, inflammasome pathway activation is responsible for the damages caused, then the inflammasome inhibitors might be considered as suitable candidates in preventing the pathological effects on the germ cells and reproductive tissues and subsequent fertility.



中文翻译:

NLRP3 炎症小体:治疗 COVID-19 和生育问题的联合潜在治疗靶点

为了克服 COVID-19 的长期后果,一种可能的方法是控制炎性体的激活,因为 SARS-CoV-2 可以诱导体液和细胞免疫反应。在这篇观点文章中,我们假设,如果有令人信服且无误的证据证明,首先,SARS-CoV-2 可以通过其在生殖组织中的共同受体进入细胞并对其造成损害,其次,炎症小体通路激活是造成损害的原因引起,那么炎性体抑制剂可能被认为是预防对生殖细胞和生殖组织的病理影响以及随后的生育能力的合适候选者。

更新日期:2021-09-23
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