The QcrB inhibitors TB47 and telacebec do not potentiate the activity of clofazimine in Mycobacterium abscessus,Antimicrobial Agents and Chemotherapy

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The QcrB inhibitors TB47 and telacebec do not potentiate the activity of clofazimine in Mycobacterium abscessus
Antimicrobial Agents and Chemotherapy ( IF 4.9 ) Pub Date : 2021-09-20 , DOI: 10.1128/aac.00964-21
Ria Sorayah _{1,

2} , Garret C Moraski ₃ , Daniel Barkan ₄ , Kevin Pethe _{2,

5}

Affiliation

The anti-tuberculosis drug telacebec is ineffective against Mycobacterium abscessus. A recent study suggested that TB47, a telacebec analogue, potentiated the efficacy of clofazimine against M. abscessus. Here, we report that TB47 is not only ineffective ...

中文翻译：

QcrB 抑制剂 TB47 和 telacebec 不会增强脓肿分枝杆菌中氯法齐明的活性

抗结核药物 telacebec 对脓肿分枝杆菌无效。最近的一项研究表明，TB47，一种 telacebec 类似物，增强了氯法齐明对脓肿分枝杆菌的疗效。在这里，我们报告说 TB47 不仅无效......

更新日期：2021-09-21

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