Gepotidacin Pharmacokinetics-Pharmacodynamics Against Escherichia coli in the One-Compartment and Hollow-Fiber In Vitro Infection Model Systems,Antimicrobial Agents and Chemotherapy

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Gepotidacin Pharmacokinetics-Pharmacodynamics Against Escherichia coli in the One-Compartment and Hollow-Fiber In Vitro Infection Model Systems
Antimicrobial Agents and Chemotherapy ( IF 4.9 ) Pub Date : 2021-09-20 , DOI: 10.1128/aac.00122-21
Brian D VanScoy ₁ , Elizabeth A Lakota ₁ , Haley Conde ₁ , Steven Fikes ₁ , Sujata M Bhavnani ₁ , Philippa B Elefante ₂ , Nicole E Scangarella-Oman ₂ , Paul G Ambrose ₁

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Gepotidacin is a novel, first-in-class triazaacenaphthylene antibiotic that inhibits bacterial DNA replication by a distinct mechanism of action with an in vitro spectrum of activity that includes Escherichia coli. Our objectives herein were the following:...

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