Sepsis represents a severe condition that predisposes patients to a high risk of death if its progression is not ended. As with other time-dependent conditions, the performance of determinant interventions has led to significant survival benefits and quality-of-care improvements in acute emergency care. Thus, the initial interventions in sepsis are a cornerstone for prognosis in most patients. Even though the evidence supporting the hour-1 bundle is perfectible, real-life application of thoughtful and organized sepsis care has improved survival and quality of care in settings promoting compliance to evidence-based treatments. Current evidence for implementing the Surviving Sepsis Campaign bundles for early sepsis management is moving forward to better approaches as more substantial evidence evolves.

脓毒症是一种严重疾病，如果其进展未结束，会使患者面临高死亡风险。与其他与时间相关的情况一样，决定性干预措施的实施已导致显着的生存益处和急性急诊护理质量的改善。因此，脓毒症的初始干预是大多数患者预后的基石。尽管支持第 1 小时捆绑的证据是完善的，但在促进循证治疗依从性的环境中，周到和有组织的脓毒症护理在现实生活中的应用提高了生存率和护理质量。随着更多实质性证据的发展，目前实施用于早期脓毒症管理的“幸存脓毒症运动”捆绑包的证据正在向更好的方法迈进。