Frontiers in Microbiology ( IF 5.2 ) Pub Date : 2021-09-21 , DOI: 10.3389/fmicb.2021.724767 Kathryn M Styles 1 , Aidan T Brown 2 , Antonia P Sagona 1
Phage therapy, the therapeutic usage of viruses to treat bacterial infections, has many theoretical benefits in the ‘post antibiotic era.’ Nevertheless, there are currently no approved mainstream phage therapies. One reason for this is a lack of understanding of the complex interactions between bacteriophage, bacteria and eukaryotic hosts. These three-component interactions are complex, with non-linear or synergistic relationships, anatomical barriers and genetic or phenotypic heterogeneity all leading to disparity between performance and efficacy in
中文翻译:
使用数学建模来提高我们对噬菌体、细菌和真核生物相互作用的理解的回顾
噬菌体疗法,即病毒治疗细菌感染的治疗用途,在“后抗生素时代”具有许多理论优势。尽管如此,目前还没有获得批准的主流噬菌体疗法。原因之一是对噬菌体、细菌和真核宿主之间复杂的相互作用缺乏了解。这些三组分相互作用是复杂的,具有非线性或协同关系、解剖障碍和遗传或表型异质性,所有这些都导致了性能和功效之间的差异。