Dual compartment suppositories are being developed to prevent HIV and other sexually transmitted infections. Such products, for use in the rectum, the vagina, or both, could have a significant public health impact by decreasing global incidence of these diseases. In this study, 16 women each used two rheologically distinct suppositories in their vagina and rectum. User Sensory Perception and Experience (USPE) scales assessed sensory experiences during sexual activity to understand whether, and how, women perceive formulation properties in the vagina and rectum. Qualitative data from individual in-depth interviews captured women's descriptions and comparisons of the experiences. Significant differences and large Cohen's d effect sizes between vaginal and rectal experiences of suppository-A were found for three scales: Application (APP): Product Awareness, SEX: Initial Penetration; and SEX: Effortful. Qualitative data provided user experience details that credibly align with these score differences. Near significant differences and large effect sizes were found for two additional scales: SEX: Perceived Wetness with suppository-A and SEX: Messiness with suppository-B. In addition, other scale scores showed medium-to-large effect sizes that correspond to hypothesized sensations associated with biophysical properties of the suppositories. Statistical significance combined with large effect sizes and qualitative data accurately represent the hypothesized perceptibility of suppository properties and identifies performance characteristics relevant to acceptability and adherence; together these data provide discernment of factors that can guide the development of dual compartment products.

中文翻译：

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设计双隔室艾滋病毒预防产品：女性对直肠和阴道栓剂的感官知觉和体验

双室栓剂正在开发中，以预防艾滋病毒和其他性传播感染。此类产品用于直肠、阴道或两者，可能会降低这些疾病的全球发病率，从而对公共卫生产生重大影响。在这项研究中，16 名女性每人在阴道和直肠中使用两种流变学不同的栓剂。用户感官知觉和体验 (USPE) 量表评估性活动期间的感官体验，以了解女性是否以及如何感知阴道和直肠中的制剂特性。来自个人深度访谈的定性数据捕捉了女性对经历的描述和比较。显着差异和大 Cohen's d栓剂 A 的阴道和直肠体验之间的效应大小在三个量表中被发现：应用（APP）：产品意识，性别：初始渗透；和性：努力。定性数据提供了与这些分数差异可靠一致的用户体验详细信息。在另外两个量表中发现了接近显着的差异和大的效应量：性别：栓剂 A 的感知湿度和性别：混乱用栓剂-B。此外，其他量表分数显示中到大的效应大小，对应于与栓剂的生物物理特性相关的假设感觉。统计显着性与大效应量和定性数据相结合，准确地代表了栓剂特性的假设可感知性，并确定了与可接受性和依从性相关的性能特征；这些数据共同提供了可以指导双室产品开发的因素的辨别力。