Owing to numerous merits, Poly(lactide-co-glycolide) (PLGA) based materials exhibit great potential in orthopedic application. However, the inherent low stiffness, poor dimensional stability and weak cell interaction are still obstacles to fulfill the role in practical application. In this study, we reported a facile production of PLGA/Poly(ε-caprolactone) (PCL) bone fixation plate with enhanced mechanical and cell adhesion properties by the micro-injection process. The in-situ fibrillation of PCL at high injection rate constructed unique parent-daughter fibril morphology, which promoted the interaction of the interfaces between the PLGA and PCL. Impressively, the tensile modulus of the as-prepared fixation plate increased from 25.64 MPa to 98.08 MPa and maintained its original dimension after 40 days immersion in aqueous conditions. The well oriented PCL fibrils with high crystallinity served as barrier in prevention of the slip PLGA molecular chain as well as the invasion of water molecules, which played a key role in promoting cell proliferation. The comprehensive properties of PLGA/PCL fixation plate not only pave a new way to enhance the short-term cell attachment/proliferation in PLGA-based materials, but also inspire the designing principle for the modification of future bone tissue engineering products.

由于具有众多优点，基于聚（丙交酯-共-乙交酯）（PLGA）的材料在骨科应用中表现出巨大的潜力。然而，固有的低刚度、差的尺寸稳定性和弱的细胞相互作用仍然是在实际应用中发挥作用的障碍。在这项研究中，我们报告了通过微注射工艺轻松生产具有增强机械和细胞粘附性能的 PLGA/聚（ε-己内酯）（PCL）骨固定板。PCL 在高注入速率下的原位原纤维化构建了独特的母子原纤维形态，促进了 PLGA 和 PCL 之间界面的相互作用。令人印象深刻的是，所制备的固定板的拉伸模量从 25.64 MPa 增加到 98.08 MPa，并在水中浸泡 40 天后保持其原始尺寸。定向良好且结晶度高的PCL原纤维作为防止PLGA分子链滑动和水分子侵入的屏障，在促进细胞增殖中起关键作用。PLGA/PCL固定板的综合性能不仅为增强PLGA基材料的短期细胞附着/增殖开辟了新途径，而且为未来骨组织工程产品的修饰提供了设计原则。