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Au-O-MWCNTs and TiO2-O-MWCNTs as Efficient Nanocarriers for Dexamethasone: Adsorption Isotherms and Kinetic Studies
International Journal of Chemical Engineering ( IF 2.7 ) Pub Date : 2021-09-21 , DOI: 10.1155/2021/2040363
Maryam Haghighi 1 , Azadeh Khoshfetrat 1
Affiliation  

In this research, the fabrication of drug delivery systems based on oxidized multiwall carbon nanotubes (O-MWCNTs) was studied. Herein, TiO2 and Au were conjugated with O-MWCNTs to prepare efficient nanocarriers for dexamethasone (dex). The samples were characterized by Fourier transform infrared (FTIR), scanning electron microscopy (SEM), and X-ray diffraction (XRD). In addition, dex loading was studied using adsorption isotherms including Langmuir, Freundlich, Temkin, and Dubinin–Radushkevich. The results show that dex adsorption agreed well with the Freundlich isotherm. Increasing the TiO2 to O-MWCNT ratio from (1 : 4) to (1 : 2) can improve the adsorption capacity from to 320 . The increasing Au amount increases the adsorption capacity from (SA1) to maximum (SA6). The maximum equilibrium binding energy was obtained for SA2, and SA7 shows high binding strength between dex and the nanoadsorbent. Carbon nanotubes (CNTs) show good affinity with high loading capabilities for dexamethasone adsorption. The synthesized TiO2-O-MWCNTs:1/2 with the maximum removal percent (80%) was proposed as an appropriate nanocarrier for dexamethasone. Pseudo-first order, pseudo-second order, Elovich, and intraparticle diffusion models were investigated for all synthesized drug nanocarriers. According to regression coefficients, experimental data are in good agreement with the pseudo-second order model for all adsorbents except O-MWCNT/CTAB. Experimental results revealed that the Elovich model could account for the O-MWCNT/CTAB adsorbent.

中文翻译:

Au-O-MWCNTs 和 TiO2-O-MWCNTs 作为地塞米松的高效纳米载体:吸附等温线和动力学研究

在这项研究中,研究了基于氧化多壁碳纳米管 (O-MWCNT) 的药物递送系统的制造。在此,TiO 2和Au与O-MWCNTs共轭以制备用于地塞米松(dex)的有效纳米载体。样品通过傅里叶变换红外 (FTIR)、扫描电子显微镜 (SEM) 和 X 射线衍射 (XRD) 进行表征。此外,使用吸附等温线研究了 dex 负载,包括 Langmuir、Freundlich、Temkin 和 Dubinin-Radushkevich。结果表明,dex吸附与Freundlich等温线非常吻合。将 TiO 2与 O-MWCNT 的比率从 (1:4) 增加到 (1:2) 可以将吸附容量从 到 320 . Au量的增加使吸附容量从 (SA1) 到最大值 (SA6)。最大平衡结合能 SA2 和 SA7 显示出 dex 和纳米吸附剂之间的高结合强度。碳纳米管 (CNTs) 显示出良好的亲和力和地塞米松吸附的高负载能力。合成的 TiO 2 -O-MWCNTs:1/2 具有最大去除百分比 (80%) 被提议作为合适的地塞米松纳米载体。研究了所有合成药物纳米载体的伪一级、伪二级、Elovich 和粒子内扩散模型。根据回归系数,实验数据与除 O-MWCNT/CTAB 之外的所有吸附剂的伪二阶模型非常吻合。实验结果表明 Elovich 模型可以解释 O-MWCNT/CTAB 吸附剂。
更新日期:2021-09-21
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