The evolution of AMPK and its homologs enabled exquisite responsivity and control of cellular energetic homeostasis. Recent work has been critical in establishing the mechanisms that determine AMPK activity, novel targets of AMPK action, and the distribution of AMPK-mediated control networks across the cellular landscape. The role of AMPK as a hub of metabolic control has led to intense interest in pharmacologic activation as a therapeutic avenue for a number of disease states, including obesity, diabetes, and cancer. As such, critical work on the compartmentalization of AMPK, its downstream targets, and the systems it influences has progressed in recent years. The variegated distribution of AMPK-mediated control of metabolic homeostasis has revealed key insights into AMPK in normal biology and future directions for AMPK-based therapeutic strategies.

AMPK 及其同系物的进化使细胞能量稳态的精确响应和控制成为可能。最近的工作对于建立决定 AMPK 活性的机制、AMPK 作用的新靶点以及 AMPK 介导的控制网络在整个细胞环境中的分布至关重要。AMPK 作为代谢控制中心的作用引起了人们对药理学激活作为许多疾病状态（包括肥胖、糖尿病和癌症）的治疗途径的浓厚兴趣。因此，近年来，关于 AMPK 的划分、其下游目标及其影响的系统的关键工作取得了进展。