Lung cancer is one of the leading causes of death among men and women worldwide. The disease initially has a silent phenotype, which leads to the progression of the disease and ultimately the lack of proper response to routine treatments. Autophagy, known as an intracellular “recycle bin” for the degradation of defective proteins and molecules, is one of the mechanisms that has been considered in the context of cancer in recent years. This study aims to provide a comprehensive review of published articles on autophagy in the context of lung cancer to have a complete view of the role of autophagy in lung cancer and its possible treatments. PubMed, Scopus, and Google Scholar were searched until June 15 to find related articles. No specific search filters or restrictions were applied. The results were entered into reference management software for aggregation and management. The full text of all articles was screened and studied. In conclusion, studies on the exact function of autophagy in lung cancer are contradictory, but what can be concluded from a review of literature on lung cancer is that targeting autophagy combined with traditional routine therapies such as chemotherapy, especially in advanced stages of lung cancer, can be an effective anticancer approach.

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自噬在肺癌中的作用、争议和联合治疗

肺癌是全球男性和女性死亡的主要原因之一。该疾病最初具有沉默表型，导致疾病进展并最终导致对常规治疗缺乏适当反应。自噬被称为细胞内“回收站”，用于降解有缺陷的蛋白质和分子，是近年来在癌症背景下考虑的机制之一。本研究旨在全面回顾已发表的关于肺癌背景下自噬的文章，以全面了解自噬在肺癌中的作用及其可能的治疗方法。搜索 PubMed、Scopus 和 Google Scholar 直到 6 月 15 日才能找到相关文章。没有应用特定的搜索过滤器或限制。结果输入参考管理软件进行汇总和管理。所有文章的全文都经过筛选和研究。总之，关于自噬在肺癌中的确切作用的研究是相互矛盾的，但通过查阅肺癌文献可以得出的结论是，靶向自噬结合化疗等传统常规疗法，尤其是在肺癌晚期，可能是一种有效的抗癌方法。