Vartak et al’s recent publicatioin reviews their previous provocative data that water flow into the bile canaliculus is not in response to an osmotic gradient, as initially proposed by Sperber. However their technique, photoactivation of a non-fluorescent precursor of fluorescein, has not been validated. In contrast, a similar technique, enzymatic activation of a non-fluorescent precursor of fluorescein supported the concept of osmotically generated canalicular water flow and confirmed that peristalsis also participates in the flow of fluid from the canaliculi into the duct system as originally described by Philips.

中文翻译：

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致编辑的信：关于胆道通量的机制

Vartak 等人最近发表的文章回顾了他们之前的激动人心的数据，即水流入胆小管并不是对渗透梯度的反应，正如 Sperber 最初提出的那样。然而，他们的技术，荧光素的非荧光前体的光活化，尚未得到验证。相比之下，一种类似的技术，荧光素的非荧光前体的酶促激活支持渗透产生的小管水流的概念，并证实蠕动也参与了流体从小管流入管道系统的流动，如飞利浦最初描述的那样。