The olfactory receptor Olfr78 (prostate-specific G protein-coupled receptor PSGR) is a member of the G protein-coupled receptor family mediating olfactory chemosensation, but it is additionally expressed in other tissues. Olfr78 expressed in kidney participates in blood pressure regulation, and in prostate it plays a role in the development of cancer. We here screened many organs/tissues of transgenic mice co-expressing β-galactosidase with Olfr78. X-gal-positive cells were detectable in smooth muscle cells of numerous arterioles of striated muscles (heart ventricles and skeletal muscles of various embryological origin). In addition, in most organs where we found expression of Olfr78 mRNA, X-gal staining was restricted to smooth muscle cells of small blood vessels. The dominant expression of Olfr78 in arteriolar smooth muscle cells supports the concept of an important role in blood pressure regulation and suggests a participation in the fine tuning of blood supply especially of striated muscles. This should be considered when targeting Olfr78 in other contexts such as prostate cancer.

嗅觉受体 Olfr78（前列腺特异性 G 蛋白偶联受体 PSGR）是介导嗅觉化学感觉的 G 蛋白偶联受体家族的成员，但它在其他组织中也有表达。在肾脏中表达的Olfr78参与血压调节，在前列腺中它在癌症的发展中起作用。我们在这里筛选了许多共表达β的转基因小鼠的器官/组织-半乳糖苷酶与 Olfr78。X-gal 阳性细胞在许多横纹肌小动脉（各种胚胎起源的心室和骨骼肌）的平滑肌细胞中可检测到。此外，在我们发现 Olfr78 mRNA 表达的大多数器官中，X-gal 染色仅限于小血管的平滑肌细胞。Olfr78 在小动脉平滑肌细胞中的主要表达支持在血压调节中起重要作用的概念，并表明参与了血液供应的微调，尤其是横纹肌。在其他情况下（如前列腺癌）中靶向 Olfr78 时应考虑这一点。