Cysticercus cellulosae (C. cellulosae) excretes and secretes antigens during the parasitic process to regulate the host immune response; however, resulting immune response and cytokine production in the host during infection still remains unclear. We used C. cellulosae crude antigens (CAs) as controls to explore the effect of excretory secretory antigens (ESAs) on T-cell immune responses in piglets. C. cellulosae ESAs induced imbalanced CD4+/CD8+ T-cell proportions, increased the CD4+Foxp3+ and CD8+Foxp3+ T-cell frequencies, and induced lymphocytes to produce interleukin-10, which was mainly attributed to CD4+ and CD4-CD8- T cells. The ESAs also induced Th2-type immune responses. The results showed that the ability of C. cellulosae to escape the host immune attacks and establish a persistent infection may be related to host immune response regulation by the ESAs.

中文翻译：

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Cysticercus cellulosae 通过排泄和分泌抗原调节 T 细胞反应并与宿主免疫系统相互作用。

Cysticercus cellulosae (C. cellulosae) 在寄生过程中排泄和分泌抗原以调节宿主免疫反应；然而，感染期间宿主产生的免疫反应和细胞因子的产生仍不清楚。我们使用纤维素粗抗原 (CA) 作为对照来探索排泄分泌抗原 (ESA) 对仔猪 T 细胞免疫反应的影响。C. cellulosae ESA 诱导 CD4+/CD8+ T 细胞比例失衡，增加 CD4+Foxp3+ 和 CD8+Foxp3+ T 细胞频率，并诱导淋巴细胞产生白细胞介素-10，主要归因于 CD4+ 和 CD4-CD8-T 细胞. ESA 还诱导 Th2 型免疫反应。结果表明，C.