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The Impact of β-1,4-Galactosyltransferase V on Microglial Function.
Frontiers in Cellular Neuroscience ( IF 5.3 ) Pub Date : 2021-09-03 , DOI: 10.3389/fncel.2021.723308
Xiaoyu Wang 1, 2 , Naiqi Shi 3 , Meiqi Hui 1 , Hui Jin 1 , Shumei Gao 1 , Qiao Zhou 1 , Li Zhang 1 , Meijuan Yan 1 , Hongmei Shen 1
Affiliation  

β-1,4 Galactosyltransferase V (β-1,4-GalT V) belongs to the β-1,4 galactosyltransferase family, which modifies proteins and plays a vital role in biological function. Our previous study revealed that β-1,4-GalT V was expressed in the cortex and hippocampus and participated in the recovery of spatial learning and memory in rats with traumatic brain injury. However, the expression of β-1,4-GalT V in microglia, resident immune cells in the central nervous system, and its impact on microglia in resting and lipopolysaccharide-triggered activated stages are elusive. In this study, we clarified that β-1,4-GalT V expresses in microglia, and it regulates microglial migration, proliferation, and release of the inflammatory factors. We also observed that β-1,4-GalT V affects the expression level of tumor necrosis factor receptor (TNFR)2 instead of TNFR1. These results strongly support the fact that β-1,4-GalT V is involved in microglial function.

中文翻译:

β-1,4-半乳糖基转移酶 V 对小胶质细胞功能的影响。

β-1,4 半乳糖基转移酶 V (β-1,4-GalT V) 属于 β-1,4 半乳糖基转移酶家族,可修饰蛋白质并在生物功能中发挥重要作用。我们之前的研究表明β-1,4-GalT V在脑外伤大鼠的皮质和海马中表达,并参与空间学习和记忆的恢复。然而,β-1,4-GalT V 在小胶质细胞(中枢神经系统中的常驻免疫细胞)中的表达及其对静息和脂多糖触发激活阶段的小胶质细胞的影响尚不清楚。在本研究中,我们阐明了 β-1,4-GalT V 在小胶质细胞中表达,并调节小胶质细胞的迁移、增殖和炎症因子的释放。我们还观察到 β-1,4-GalT V 影响肿瘤坏死因子受体 (TNFR)2 而不是 TNFR1 的表达水平。
更新日期:2021-09-03
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