The failure of axonal regeneration after spinal cord injury (SCI) results in permanent loss of sensorimotor function. The persistent presence of scar tissue, mainly fibrotic scar and astrocytic scar, is a critical cause of axonal regeneration failure and is widely accepted as a treatment target for SCI. Astrocytic scar has been widely investigated, while fibrotic scar has received less attention. Here, we review recent advances in fibrotic scar formation and its crosstalk with other main cellular components in the injured core after SCI, as well as its cellular origin, function, and mechanism. This study is expected to provide an important basis and novel insights into fibrotic scar as a treatment target for SCI.

中文翻译：

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脊髓损伤后的纤维化疤痕：与其他细胞的串扰、细胞起源、功能和机制。

脊髓损伤 (SCI) 后轴突再生的失败导致感觉运动功能的永久性丧失。瘢痕组织的持续存在，主要是纤维化瘢痕和星形细胞瘢痕，是轴突再生失败的关键原因，被广泛接受为 SCI 的治疗靶点。星形细胞瘢痕已被广泛研究，而纤维化瘢痕较少受到关注。在这里，我们回顾了纤维化瘢痕形成的最新进展及其与 SCI 后损伤核心中其他主要细胞成分的串扰，以及其细胞起源、功能和机制。这项研究有望为纤维化瘢痕作为 SCI 的治疗目标提供重要的基础和新的见解。