Coordination Chemistry Reviews ( IF 20.6 ) Pub Date : 2021-09-20 , DOI: 10.1016/j.ccr.2021.214193 Praveen Kumar Singh 1, 2 , Poulomi Majumdar 1 , Surya Prakash Singh 1, 2
Photoactivatable protecting groups (PPGs) or caged compounds are beneficial tools for spatiotemporal controlled release of bioagents, fluorescent probes, polymerization initiators and gasotransmitters such as carbonmonoxide, nitric oxide, and hydrogen sulfide. Most of the reported PPGs absorbs in the UV light, suffers from poor tissue penetrations and undesirable photochemical transformation whereas visible/NIR light has better tissue penetration and less bio autofluorescence and has attracted researchers to develop PPGs activated by visible/NIR light. Thus, visible/NIR light absorbing BODIPY PPGs with easily tunable spectral properties and low phototoxicity are used for non-invasive photorelease of protecting groups. The review will mainly focus on the advance research on the molecular designing, spectroscopic properties, structure activity relationship, discussions of photorelease mechanisms and applications (wherever applicable) of visible/red light absorbing photoactivatable BODIPY fluorophore as PPGs. We strongly believe that this review will present a broad perspective for BODIPY dyes as PPGs and provide guidance to the beginners and young researchers for the rational designing of BODIPY based fluorescent dyes of biological importance.
中文翻译:
BODIPY 光裂解保护基的研究进展
光活化保护基团 (PPG) 或笼状化合物是生物制剂、荧光探针、聚合引发剂和气体传输剂(如一氧化碳、一氧化氮和硫化氢)时空控制释放的有益工具。大多数报道的 PPG 吸收紫外线,组织穿透性差和光化学转化不良,而可见光/近红外光具有更好的组织穿透性和较少的生物自发荧光,吸引了研究人员开发由可见光/近红外光激活的 PPG。因此,具有易调谐光谱特性和低光毒性的可见光/近红外光吸收 BODIPY PPG 可用于保护基团的非侵入性光释放。综述将主要集中在分子设计、光谱特性、构效关系,讨论光释放机制和可见光/红光吸收光活化 BODIPY 荧光团作为 PPG 的应用(在适用的情况下)。我们坚信,这篇综述将为 BODIPY 染料作为 PPG 提供广阔的前景,并为初学者和年轻研究人员合理设计具有生物学重要性的 BODIPY 荧光染料提供指导。