PURPOSE

To elucidate clinical factors related to the presence of loculation of fluid (LOF) in the posterior choroid in central serous chorioretinopathy (CSC).

DESIGN

Retrospective, cross-sectional study.

METHODS

This single-center study included 158 eyes from 158 patients with CSC who were classified into LOF and non-LOF groups. The groups were compared for age, sex, spherical equivalent, axial length, subfoveal choroidal thickness (SCT), and scleral thickness. Using swept-source optical coherence tomography (OCT), we determined the presence of LOF based on B-scan and en face images. Scleral thickness was measured 6 mm posterior to the scleral spur in 4 directions using anterior-segment OCT.

RESULTS

The 158 eyes were classified into 98 eyes in the LOF group and 60 eyes in the non-LOF group. In univariable analyses, the LOF group was younger (P = .01) and had a higher male ratio (P = .03) and greater SCT (P < .001) than the non-LOF group. All scleral thicknesses at the superior, temporal, inferior, and nasal points were greater in the LOF group than in the non-LOF group (426.2 vs 395.1 μm, 445.7 vs 414.9 μm, 459.2 vs 428.8 μm, 445.4 vs 414.3 μm, all P < .05). Multivariable analyses found that SCT (odds ratio [OR] 1.02, 95% CI 1.01-1.02, P < .001) and mean scleral thickness (OR 1.02, 95% CI 1.02-1.03, P = .002) were significantly associated with the presence of LOF.

CONCLUSION

A thick choroid and thick sclera appeared to be related to the presence of LOF in CSC.

中文翻译：

---

与中心性浆液性脉络膜视网膜病变液体定位相关的临床因素

目的

阐明与中心性浆液性脉络膜视网膜病变 (CSC) 后脉络膜中存在液体沉积 (LOF) 相关的临床因素。

设计

回顾性横断面研究。

方法

这项单中心研究包括来自 158 名 CSC 患者的 158 只眼，这些患者分为 LOF 组和非 LOF 组。比较各组的年龄、性别、等效球体、轴向长度、中心凹下脉络膜厚度 (SCT) 和巩膜厚度。使用扫描源光学相干断层扫描 (OCT)，我们根据 B 扫描和正面图像确定了 LOF 的存在。使用前段 OCT 在 4 个方向上测量巩膜骨刺后 6 毫米处的巩膜厚度。

结果

158眼分为LOF组98眼和非LOF组60眼。在单变量分析中，与非 LOF 组相比，LOF 组更年轻 ( P  = .01)，男性比例更高 ( P  = .03) 和更大的 SCT ( P < .001)。LOF 组上、颞、下和鼻点的所有巩膜厚度均大于非 LOF 组（426.2 vs 395.1 μm，445.7 vs 414.9 μm，459.2 vs 428.8 μm，445.4 vs 414.3 μm，所有P < .05)。多变量分析发现，SCT（优势比 [OR] 1.02, 95% CI 1.01-1.02, P < .001）和平均巩膜厚度（OR 1.02, 95% CI 1.02-1.03, P  = .002）与LOF 的存在。

结论

厚的脉络膜和厚的巩膜似乎与 CSC 中 LOF 的存在有关。