PURPOSE

To describe the effectiveness and side effect profile of difluprednate therapy in a series of patients with anterior scleritis.

DESIGN

Retrospective, interventional case series.

METHODS

Data collected from all patients with anterior scleritis who used difluprednate as a single treatment agent from January 1, 2018, to January 1, 2020, including demographics, scleritis type, presence of nodules or necrosis, changes in scleritis activity, intraocular pressure (IOP), number of difluprednate drops used, best-corrected visual acuity (BCVA), and lens status. The primary outcome was clinical resolution of scleritis. Secondary outcomes included BCVA loss ≥2 lines, change in lens status or cataract surgery, and IOP ≥24 mm Hg.

RESULTS

Twenty-five patients (35 eyes) were analyzed. The median age was 60 years (range 13-78); 60% were female; 64% were White. Forty percent had bilateral disease, and 44% of patients had an associated systemic disease. The majority of eyes (66%) had diffuse anterior scleritis. Eighty-three percent of eyes achieved resolution of scleritis, with a median time of resolution of 6 weeks. Eyes treated with an initial dose of ≥4 times daily were more likely to achieve disease resolution (hazard ratio [HR] = 3.43, 95% confidence interval [CI] 1.19, 9.88, P = .02). Nine eyes had IOP elevation. Four eyes lost ≥2 lines of BCVA, and 1 due to cataract progression. One eye underwent cataract surgery.

CONCLUSIONS

Difluprednate alone may effectively treat non-infectious anterior scleritis with a tolerable side effect profile.

中文翻译：

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二氟泼尼酯治疗前巩膜炎的疗效

目的

描述二氟泼尼酯治疗一系列前巩膜炎患者的有效性和副作用。

设计

回顾性、介入性病例系列。

方法

从 2018 年 1 月 1 日至 2020 年 1 月 1 日，从所有使用二氟泼尼酯作为单一治疗药物的前巩膜炎患者收集的数据，包括人口统计学、巩膜炎类型、结节或坏死的存在、巩膜炎活动的变化、眼压 (IOP) 、使用的二氟泼尼酯滴剂数量、最佳矫正视力 (BCVA) 和晶状体状态。主要结果是巩膜炎的临床消退。次要结局包括 BCVA 损失≥2 线、晶状体状态改变或白内障手​​术以及眼压≥24 mm Hg。

结果

分析了 25 名患者（35 只眼）。中位年龄为 60 岁（范围 13-78）；60% 是女性；64% 是白人。40% 患有双侧疾病，44% 的患者患有相关的全身性疾病。大多数眼睛（66%）患有弥漫性前巩膜炎。83% 的眼睛实现了巩膜炎的消退，中位消退时间为 6 周。接受每日 ≥ 4 次初始剂量治疗的眼睛更有可能实现疾病消退（风险比 [HR] = 3.43, 95% 置信区间 [CI] 1.19, 9.88, P  = .02）。九只眼睛有眼压升高。四只眼睛失去了≥2 行 BCVA，1 只眼睛因白内障进展而丢失。一只眼睛接受了白内障手术。

结论

单独使用二氟泼尼酯可有效治疗非感染性前巩膜炎，且副作用可耐受。