ABSTRACT

Cardiovascular diseases are the leading cause of death in the world and scientists pay a lot of attention to identify and reveal the mechanisms of their occurrence. Recently, the attention of scientists is focused increasingly on plant derivatives, such as flavonoids and polyphenols, due to their specific biological effects. One of these compounds is curcumin, which has many biological properties. Numerous studies have been performed to understand the molecular basis of the therapeutic properties of curcumin. As a result of these studies, there is considerable evidence to suggest that curcumin may affect signaling pathways associated with the cell growth, proliferation, survival, inflammation, and gene transcription. Antioxidant and anti-inflammatory mechanisms are the two basic mechanisms to which many of the effects of curcumin in various conditions are attributed. Many factors influence the development of heart disease, but one of the main culprits in their occurrence is the inflammatory process. According to recent research, curcumin is an ingredient that could be used in the prevention or treatment of cardiovascular disease. Also, some studies have shown that it has beneficial effects in preventing vascular damage and ischemia. Despite its beneficial and biological properties, it has been proven that curcumin has relatively low bioavailability and low stability in the human body, which limits its therapeutic application. In this regard, several attempts have been made to synthesize curcumin derivatives with improved bioavailability. In this paper, we review the potential and possibilities of using curcumin and its derivatives in the treatment of cardiovascular disease, which would significantly reduce the mortality rate in the population. Based on all of the above, it can be concluded that further studies of animal models and humans are needed to verify current knowledge about the application of curcumin and its derivatives in the treatment of cardiovascular diseases. In this way through these studies more reliable data will be generated concerning the effects of curcumin and its analogs on cellular and subcellular/molecular levels. Prospectively, we believe that this will ground the basis for further improved synthesis of curcumin-analogs, appropriate for the treatment of cardiovascular diseases.

摘要

心血管疾病是世界上主要的死亡原因，科学家们非常重视识别和揭示其发生机制。最近，由于其特定的生物效应，科学家的注意力越来越集中在植物衍生物上，例如黄酮类和多酚类。其中一种化合物是姜黄素，它具有许多生物学特性。已经进行了大量研究以了解姜黄素治疗特性的分子基础。作为这些研究的结果，有大量证据表明姜黄素可能影响与细胞生长、增殖、存活、炎症和基因转录相关的信号通路。抗氧化和抗炎机制是姜黄素在各种条件下的许多作用所归因的两种基本机制。许多因素影响心脏病的发展，但其发生的罪魁祸首之一是炎症过程。根据最近的研究，姜黄素是一种可用于预防或治疗心血管疾病的成分。此外，一些研究表明，它在预防血管损伤和缺血方面具有有益作用。尽管具有有益的生物学特性，但已经证明姜黄素在人体内的生物利用度较低，稳定性较低，这限制了其治疗应用。在这方面，已经进行了多次尝试以合成具有改善的生物利用度的姜黄素衍生物。在本文中，我们回顾了使用姜黄素及其衍生物治疗心血管疾病的潜力和可能性，这将显着降低人口死亡率。综上所述，可以得出结论，需要进一步对动物模型和人体进行研究，以验证目前关于姜黄素及其衍生物在治疗心血管疾病中的应用的知识。这样，通过这些研究，将产生关于姜黄素及其类似物对细胞和亚细胞/分子水平的影响的更可靠的数据。展望未来，我们相信这将为进一步改进姜黄素类似物的合成奠定基础，适用于治疗心血管疾病。