Retinoic acid receptor responder protein 1 (RARRES1) has been identified as a novel gene for the regulation of podocyte function, and its expression is increased in glomerular disease and associated with disease progression. Increased expression of RARRES1 in podocytes leads to apoptosis through an autocrine effect. Möller-Hackbarth et al. recently found that RARRES1 expression is increased in the endothelial cells in some diseased kidneys to promote podocyte injury, likely through a paracrine effect.

中文翻译：

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新型足细胞基因 RARRES1 的自分泌和旁分泌作用

视黄酸受体反应蛋白 1 (RARRES1) 已被确定为调节足细胞功能的新基因，其表达在肾小球疾病中增加并与疾病进展相关。足细胞中 RARRES1 表达的增加通过自分泌效应导致细胞凋亡。穆勒-哈克巴特等人。最近发现，一些患病肾脏的内皮细胞中 RARRES1 表达增加，可能通过旁分泌作用促进足细胞损伤。