Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a biosafety level (BSL)-3 pathogen; therefore, its research environment is strictly limited. Pseudotyped viruses that mimic SARS-CoV-2 have been widely used for in vitro evaluation because they are available in BSL-2 containment laboratories; however, in vivo application is inadequate. Therefore, animal models that can be instigated with animal BSL-2 will increase opportunities for in vivo evaluations.

中文翻译：

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使用假型病毒的新型 SARS-CoV-2 呼吸道感染仓鼠模型

背景严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 是一种生物安全级别 (BSL)-3 病原体；因此，其研究环境受到严格限制。模拟 SARS-CoV-2 的假型病毒已被广泛用于体外评估，因为它们可在 BSL-2 遏制实验室获得；然而，体内应用是不够的。因此，可以用动物 BSL-2 启动的动物模型将增加体内评估的机会。