The crosslinked gelatin/chitosan/poly(vinyl alcohol)/hydroxyapatite (GEL/CTS/PVA/HAp, GCPH) sponges were fabricated by a freeze-drying method to yield the reinforced composite sponges with proper features. The porosity value and pore size of the crosslinked GCPH sponges reached ∼80% and 50–100 ​μm, respectively, which can be an appropriate range to allow cells to migrate into the reinforced composite sponges in the tissue engineering technology. Besides, the proper bonding presence between HAp particles and the crosslinked polymeric matrix or the crosslinked network formation between the polymers were also proved through fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermal gravimetric (TG/DTG) analysis. Owing to incorporation of HAp particles and good distribution of HAp particles inside the crosslinked polymeric matrix, their mechanical properties were improved through the determination of compression tests. Concomitantly, their water absorption ability reached effectively in both the distilled water and NaCl solution, and their recovery also maintained well for 10 absorbing–squeezing cycles to be considered as an effective reusability for the crosslinked sponge system. Thereby, the crosslinked GCPH sponge prepared in the present study can become a potential candidate to apply especially in the biomedical/medical applications and tissue engineering technology.

交联明胶/壳聚糖/聚乙烯醇/羟基磷灰石（GEL/CTS/PVA/HAp，GCPH）海绵通过冷冻干燥方法制备，得到具有适当特性的增强复合海绵。交联GCPH海绵的孔隙率值和孔径分别达到~80%和50-100μm，这是组织工程技术中允许细胞迁移到增强复合海绵中的合适范围。此外，还通过傅里叶变换红外光谱 (FTIR)、X 射线衍射 (XRD) 和热重分析 (TG/DTG) 证明了 HAp 颗粒与交联聚合物基质之间的适当键合或聚合物之间的交联网络形成。分析。由于 HAp 颗粒的掺入和 HAp 颗粒在交联聚合物基质内的良好分布，它们的机械性能通过压缩试验的测定得到了改善。同时，它们在蒸馏水和 NaCl 溶液中的吸水能力均达到有效，并且它们的回收率在 10 次吸收-挤压循环中也保持良好，被认为是交联海绵系统的有效可重复使用性。因此，本研究中制备的交联 GCPH 海绵可以成为潜在的候选者，特别是在生物医学/医学应用和组织工程技术中的应用。它们在蒸馏水和 NaCl 溶液中的吸水能力均达到有效，并且它们的回收率在 10 个吸收-挤压循环中也保持良好，被认为是交联海绵系统的有效可重复使用性。因此，本研究中制备的交联 GCPH 海绵可以成为潜在的候选者，特别是在生物医学/医学应用和组织工程技术中的应用。它们在蒸馏水和 NaCl 溶液中的吸水能力均达到有效，并且它们的回收率在 10 个吸收-挤压循环中也保持良好，被认为是交联海绵系统的有效可重复使用性。因此，本研究中制备的交联 GCPH 海绵可以成为潜在的候选者，特别是在生物医学/医学应用和组织工程技术中的应用。