Discovery of a glucosylgalactose phosphorylase: Although the rapidly expanding sequence space offers excellent opportunities for the discovery of novel enzymes, its rational exploration is key to the effective localization of regions for which no functional information is available. We have applied a binary approach that leverages the strengths of phylogeny and sequence similarity networks and which led to the discovery of the novel 4-O-β-d-glucosyl-d-galactose phosphorylase.

中文翻译：

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用于酶发现的 GH94 序列空间的探索揭示了一种新的葡萄糖基半乳糖磷酸化酶特异性

发现葡萄糖基半乳糖磷酸化酶：尽管快速扩展的序列空间为发现新酶提供了极好的机会，但其合理探索是有效定位没有功能信息的区域的关键。我们应用了一种二元方法，该方法利用了系统发育和序列相似性网络的优势，从而发现了新型 4 - O -β- d-葡糖基-d-半乳糖磷酸化酶。