Background: Intestinal flora is associated with Graves’ disease (GD). This study explored the association of serum 25(OH)D with the diversity of the intestinal flora and serum IL-17 in GD patients. Methods: Patients newly diagnosed with GD at 2 centers between 2018 and 2021 were consecutively included. According to their 25(OH)D levels, they were divided into the deficiency group, the insufficiency group, and the sufficiency group. Some patients with vitamin D deficiency or insufficiency were randomly selected and were matched with healthy volunteers (normal control [NC]) in terms of sex, age, and case number. The diversity and differential species of the intestinal flora and serum IL-17 levels were compared. Results: Serum 25(OH)D negatively correlated with serum IL-17, the platelet/lymphocyte ratio, and TSH receptor antibody. The diversity of the intestinal flora decreased in the GD group, with noticeable differences in the composition of the intestinal flora when compared with the NC group. At the phylum level, the GD group exhibited a significantly lower abundance of Firmicutes but a higher abundance of Actinobacteria. At the genus level, the GD group exhibited higher relative abundances of Bifidobacterium, Collinsella, and Pediococcus but lower abundances of Roseburia and Dialister. Conclusions: The changes in the vitamin D level and the composition of the intestinal flora may partially contribute to the development of GD.
Int Arch Allergy Immunol

中文翻译：

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格雷夫斯病合并维生素 D 缺乏症患者肠道菌群和血清 IL-17 水平的变化

背景：肠道菌群与格雷夫斯病 (GD) 相关。本研究探讨了 GD 患者血清 25(OH)D 与肠道菌群多样性和血清 IL-17 的关系。方法：连续纳入2018-2021年2个中心新诊断的GD患者。根据其25(OH)D水平分为缺乏组、不足组和充足组。随机选择一些维生素 D 缺乏或不足的患者，并在性别、年龄和病例数方面与健康志愿者（正常对照 [NC]）进行匹配。比较肠道菌群的多样性和差异物种及血清IL-17水平。结果：血清 25(OH)D 与血清 IL-17、血小板/淋巴细胞比率和 TSH 受体抗体呈负相关。GD组肠道菌群多样性降低，与NC组相比肠道菌群组成存在明显差异。在门水平上，GD 组的厚壁菌门丰度显着降低，但放线菌的丰度较高。在属水平上，GD 组的双歧杆菌、柯林斯菌和片球菌的相对丰度较高，但罗氏菌属和 Dialister 的丰度较低。结论：维生素D水平和肠道菌群组成的变化可能部分促成了GD的发生。
Int Arch 过敏免疫