The knowledge of the fate of metal-containing nanoparticles in biological media in aqueous media is of utmost importance for the future use of these promising theranostic agents for clinical applications. A methodology based on the combination of TDA-ICP-MS and CE-ICP-MS was applied to study the degradation pathway of AGuIX, a phase 2 clinical ultrasmall gadolinium-containing nanoparticle. Nanoparticle size measurements and gadolinium speciation performed in different media (phosphate buffer, urine and serum) demonstrated an accelerated dissolution of AGuIX in serum, without any release of free gadolinium for each medium.

中文翻译：

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金属基超小纳米粒子的生物降解：使用 TDA-ICP-MS 和 CE-ICP-MS 的组合方法

了解含水介质中生物介质中含金属纳米颗粒的命运对于这些有前途的治疗诊断剂在临床应用中的未来使用至关重要。应用基于 TDA-ICP-MS 和 CE-ICP-MS 组合的方法研究 AGuIX（一种 2 期临床超小含钆纳米颗粒）的降解途径。在不同介质（磷酸盐缓冲液、尿液和血清）中进行的纳米颗粒尺寸测量和钆形态分析表明，AGuIX 在血清中的溶解加速，每种介质没有任何游离钆释放。