Since the aggregation induced emission (AIE) phenomenon was reported, many research groups have used this unique AIE effect to develop chemo- or bio-sensors for detecting ions, gases, explosives, proteins, and enzymes. Most of these sensors work in their aggregate state, therefore, fluorescence stability has become one of the important problem, and unfortunately, as far as we know, there is no paper to discuss what factors can improve the fluorescence stability of AIE compounds in the aggregate state, if the fluorescence stability of the sensors are poor, there will seriously affect the detection result. In this article, we found that compounds with hydrophobic long alkyl substituents can maintain stable fluorescence intensity for a long time in the aggregate state. In addition, cyclohexane is introduced as a hydrophobic substituent. Therefore, the fluorescence stability of the aggregates also increased by 90% within 1800s. The aggregation solutions of CB-3 and CSB-2 were left for two weeks, and no significant changes were found in the fluorescence intensity. Molecular dynamics simulation (MDS) shows that the presence of hydrophobic substituents in compounds cause the molecules to be closely interspersed with each other, hence, making it difficult to change the optical properties, microstructure and stacking mode of the AIE aggregates by external stimulations. The introduction of hydrophobic substituents improves the fluorescence stability of AIE compounds, and makes the AIE phenomenon more valuable in the fields of biological/chemical sensing and imaging.

自从报道了聚集诱导发射 (AIE) 现象以来，许多研究小组已经利用这种独特的 AIE 效应开发了化学或生物传感器，用于检测离子、气体、爆炸物、蛋白质和酶。这些传感器大多在聚合状态下工作，因此荧光稳定性成为重要问题之一，不幸的是，据我们所知，目前还没有论文讨论哪些因素可以提高聚合中AIE化合物的荧光稳定性状态，如果传感器的荧光稳定性差，将严重影响检测结果。在本文中，我们发现具有疏水性长烷基取代基的化合物可以在聚集状态下长时间保持稳定的荧光强度。此外，还引入了环己烷作为疏水性取代基。所以，聚集体的荧光稳定性在 1800 秒内也提高了 90%。CB-3和CSB-2的聚集溶液放置两周，荧光强度未见明显变化。分子动力学模拟 (MDS) 表明，化合物中疏水取代基的存在导致分子间紧密散布，因此很难通过外部刺激改变 AIE 聚集体的光学性质、微观结构和堆积模式。疏水取代基的引入提高了AIE化合物的荧光稳定性，使AIE现象在生物/化学传感和成像领域更有价值。CB-3和CSB-2的聚集溶液放置两周，荧光强度未见明显变化。分子动力学模拟 (MDS) 表明，化合物中疏水取代基的存在导致分子间紧密散布，因此很难通过外部刺激改变 AIE 聚集体的光学性质、微观结构和堆积模式。疏水取代基的引入提高了AIE化合物的荧光稳定性，使AIE现象在生物/化学传感和成像领域更有价值。CB-3和CSB-2的聚集溶液放置两周，荧光强度未见明显变化。分子动力学模拟 (MDS) 表明，化合物中疏水取代基的存在导致分子间紧密散布，因此很难通过外部刺激改变 AIE 聚集体的光学性质、微观结构和堆积模式。疏水取代基的引入提高了AIE化合物的荧光稳定性，使AIE现象在生物/化学传感和成像领域更有价值。分子动力学模拟 (MDS) 表明，化合物中疏水取代基的存在导致分子间紧密散布，因此很难通过外部刺激改变 AIE 聚集体的光学性质、微观结构和堆积模式。疏水取代基的引入提高了AIE化合物的荧光稳定性，使AIE现象在生物/化学传感和成像领域更有价值。分子动力学模拟 (MDS) 表明，化合物中疏水取代基的存在导致分子间紧密散布，因此很难通过外部刺激改变 AIE 聚集体的光学性质、微观结构和堆积模式。疏水取代基的引入提高了AIE化合物的荧光稳定性，使AIE现象在生物/化学传感和成像领域更有价值。