Introduction: COVID-19 affects multiple organ systems causing substantial long-term morbidity. The implications of the Post-Acute Sequelae of SARS-CoV-2 infection, particularly for primary care, remain unknown. This cross-sectional study examines new symptoms reported at primary care encounters during three post-acute follow-up intervals after initial SARS-CoV-2 infection. Methods: Electronic health record data from the NYU Langone COVID Deidentified Dataset were queried for adults with a positive SARS-CoV-2 PCR test, and then restricted to those with a new ICD-10-CM code documented at a post-acute COVID-related primary care follow-up >14 days after testing positive. New diagnoses and the corresponding Clinical Classifications Software Refined categories were assessed at the following intervals: 0.5–3 months (“subacute”), 3–6 months (“prolonged”), and 6–9 months (“persistent”). Results: Out of 3,154 patients, a new ICD-10-CM code was documented among 499 patients (∼16%). Respiratory complaints, including cough, shortness of breath, dyspnea, and hypoxemia, were most common. Malaise and fatigue were reported consistently among 10–13% of patients at all three time-intervals. Musculoskeletal pain, circulatory symptoms, and sleep-wake disorders were also observed at primary care follow-up. Conclusion: This cross-sectional study provides support of a post-acute COVID syndrome, demonstrating that patients continue to experience symptoms after the acute infection period. Extensive follow-up data allowed for examining new symptoms up to 9 months after initial SARS-CoV-2 infection. Understanding of the course of multi-organ post-acute sequelae is restricted by cross-sectional study design limitations. Standardized, sequelae-related ICD-10-CM codes to specify the type and duration of post-acute COVID-related symptoms would enable better monitoring of the growing number of SARS-CoV-2 infection survivors.

中文翻译：

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监测纽约市初级保健患者感染 COVID-19 后的新症状

简介：COVID-19 影响多个器官系统，导致大量的长期发病率。SARS-CoV-2 感染的急性后后遗症的影响，特别是对初级保健的影响，仍然未知。这项横断面研究检查了在最初感染 SARS-CoV-2 后的三个急性后随访间隔期间初级保健就诊时报告的新症状。方法：针对 SARS-CoV-2 PCR 检测呈阳性的成年人，查询来自纽约大学 Langone COVID 识别数据集的电子健康记录数据，然后仅限于那些在急性 COVID-相关初级保健随访 > 14 天后检测呈阳性。新诊断和相应的临床分类软件精炼类别按以下时间间隔进行评估：0.5-3 个月（“亚急性”），3-6 个月（“延长”）和 6-9 个月（“持续”）。结果：在 3,154 名患者中，499 名患者（约 16%）记录了新的 ICD-10-CM 代码。呼吸系统疾病，包括咳嗽、呼吸急促、呼吸困难和低氧血症，是最常见的。在所有三个时间间隔内，10-13% 的患者均报告有不适和疲劳。在初级保健随访中也观察到肌肉骨骼疼痛、循环系统症状和睡眠-觉醒障碍。结论：这项横断面研究为急性 COVID 后综合征提供了支持，表明患者在急性感染期后继续出现症状。大量的随访数据允许检查最初感染 SARS-CoV-2 后长达 9 个月的新症状。对多器官急性后遗症病程的理解受到横断面研究设计的限制。标准化的、与后遗症相关的 ICD-10-CM 代码用于指定急性 COVID 相关症状的类型和持续时间，这将有助于更好地监测越来越多的 SARS-CoV-2 感染幸存者。