Jasminum sambac (L.) is a South Asian folkloric medicinal plant that has traditionally been used to treat cardiovascular problems. The current investigation was meticulously organized to explore the pharmacological foundation for the medicinal uses of J. sambac pertaining to cardiovascular ailments and to investigate the core mechanisms. Mechanistic investigation revealed that crude leaf extract of J. sambac produced ex-vivo vasorelaxant effects in endotheliumintact aorta ring preparation and hypotensive effect was recorded via pressure and force transducers coupled to the Power Lab Data Acquisition System. Moreover; J. sambac showed cardioprotective effects against adrenaline -induced left ventricular hypertrophy in rabbits observed hemodynamic. CK-MB, LDH, troponin, CRP, ALT, AST, ALP levels were shown to be lower in the myocardial infarction model, as were necrosis, oedema, and inflammatory cell recruitment in comparison to control. J. sambac has shown good antioxidant potential as well as prolonged the noradrenaline induced platelet adhesion. The vasorelaxant and cardioprotective effects in both in vivo and ex vivo experiments, which are enabled by activation of muscarinic receptor and/or releasing the nitric oxide and by reducing the adrenaline, induced oxidative stress, justifying its usage in cardiovascular disorders.

中文翻译：

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Jasminum sambac：治疗心血管疾病的药物开发的潜在候选者

Jasminum sambac (L.) 是一种南亚民间药用植物，传统上用于治疗心血管问题。目前的调查是精心组织的，以探索沙巴克与心血管疾病相关的药理基础，并研究其核心机制。机理研究表明，沙巴氏菌的粗叶提取物在内皮完整的主动脉环制备中产生了体外血管舒张作用，并且通过与 Power Lab 数据采集系统耦合的压力和力传感器记录了降压作用。而且; J. 沙巴克在观察到的血流动力学中显示出对肾上腺素引起的左心室肥大的心脏保护作用。与对照组相比，心肌梗死模型中的 CK-MB、LDH、肌钙蛋白、CRP、ALT、AST、ALP 水平较低，坏死、水肿和炎症细胞募集的水平也较低。J. sambac显示出良好的抗氧化潜力以及延长去甲肾上腺素诱导的血小板粘附。通过激活毒蕈碱受体和/或释放一氧化氮和通过减少肾上腺素，在体内和体外实验中产生血管舒张和心脏保护作用，诱导氧化应激，证明其在心血管疾病中的使用是合理的。