Green Chemistry has become in the last two decades an increasing part of research interest. Nonconventional «green» sources for chemical reactions include micro-wave, mechanical mixing, visible light and ultrasound. 1,2,3-triazoles have important applications in pharmaceutical chemistry while their 1,2,4 counterparts are developed to a lesser extent. In the review presented here we will focus on synthesis of 1,2,3 and 1,2,4-triazole systems by means of classical and « green chemistry » conditions involving ultrasound chemistry and mechanochemistry. The focus will be on compounds/scaffolds that possess biological/pharmacophoric properties. Finally, we will also present the formal cycloreversion of 1,2,3-triazole compounds under mechanical forces and its potential use in biological systems.

中文翻译：

---

生物相关 1,2,3- 和 1,3,4-三唑的合成：从经典途径到绿色化学

在过去的二十年中，绿色化学已成为越来越多的研究兴趣。化学反应的非常规“绿色”光源包括微波、机械混合、可见光和超声波。1,2,3-三唑在药物化学中具有重要应用，而其 1,2,4 对应物的开发程度较低。在这里介绍的综述中，我们将重点介绍通过涉及超声化学和机械化学的经典和“绿色化学”条件合成 1,2,3 和 1,2,4-三唑系统。重点将放在具有生物/药效特性的化合物/支架上。最后，我们还将介绍 1,2,3-三唑化合物在机械力下的正式环回复及其在生物系统中的潜在用途。