The loss of skin integrity is inevitable in life. Wound healing is a necessary sequence of events to reconstitute the body’s integrity against potentially harmful environmental agents and restore homeostasis. Attempts to improve cutaneous wound healing are therefore as old as humanity itself. Furthermore, nowadays, targeting defective wound healing is of utmost importance in an aging society with underlying diseases such as diabetes and vascular insufficiencies being on the rise. Because chronic wounds’ etiology and specific traits differ, there is widespread polypragmasia in targeting non-healing conditions. Reactive oxygen and nitrogen species (ROS/RNS) are an overarching theme accompanying wound healing and its biological stages. ROS are signaling agents generated by phagocytes to inactivate pathogens. Although ROS/RNS’s central role in the biology of wound healing has long been appreciated, it was only until the recent decade that these agents were explicitly used to target defective wound healing using gas plasma technology. Gas plasma is a physical state of matter and is a partially ionized gas operated at body temperature which generates a plethora of ROS/RNS simultaneously in a spatiotemporally controlled manner. Animal models of wound healing have been vital in driving the development of these wound healing-promoting technologies, and this review summarizes the current knowledge and identifies open ends derived from in vivo wound models under gas plasma therapy. While gas plasma-assisted wound healing in humans has become well established in Europe, veterinary medicine is an emerging field with great potential to improve the lives of suffering animals.

中文翻译：

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动物模型和兽医学中的气体等离子体增强伤口愈合

皮肤完整性的丧失在生活中是不可避免的。伤口愈合是一系列必要的事件，以重建身体的完整性以抵御潜在的有害环境因素并恢复体内平衡。因此，改善皮肤伤口愈合的尝试与人类本身一样古老。此外，如今，在糖尿病和血管功能不全等潜在疾病不断增加的老龄化社会中，针对有缺陷的伤口愈合至关重要。由于慢性伤口的病因和具体特征不同，针对不愈合条件存在广泛的多语症。活性氧和氮物质 (ROS/RNS) 是伴随伤口愈合及其生物学阶段的首要主题。ROS 是吞噬细胞产生的信号剂，用于灭活病原体。尽管 ROS/RNS 在伤口愈合生物学中的核心作用早已得到认可，但直到最近十年，这些药物才被明确用于使用气体等离子体技术靶向有缺陷的伤口愈合。气体等离子体是物质的一种物理状态，是一种在体温下运行的部分电离气体，它以时空控制的方式同时产生大量的 ROS/RNS。伤口愈合的动物模型在推动这些伤口愈合促进技术的发展方面起到了至关重要的作用，本综述总结了当前的知识并确定了来自气体等离子体治疗下的体内伤口模型的开放端。虽然气体等离子体辅助人体伤口愈合在欧洲已经很成熟，