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RANTES 59029A/G Polymorphisms Associated with Diabetic Compilations in Korean Patients with Type 2 Diabetes for over 15 Years
Genes ( IF 3.5 ) Pub Date : 2021-09-19 , DOI: 10.3390/genes12091445 Dong-Hwa Lee 1 , Eu-Jeong Ku 1 , Tae-Keun Oh 1 , Hyun-Jeong Jeon 1
Genes ( IF 3.5 ) Pub Date : 2021-09-19 , DOI: 10.3390/genes12091445 Dong-Hwa Lee 1 , Eu-Jeong Ku 1 , Tae-Keun Oh 1 , Hyun-Jeong Jeon 1
Affiliation
Background: Polymorphisms in the RANTES gene are known to be associated with several diseases related to insulin resistance. In this study, we investigated the association between RANTES 59029A/G polymorphisms and the prevalence of diabetic complications relative to obesity in Korean patients who had type 2 diabetes (T2D) for over 15 years. Methods: A single-center, retrospective case-control study was performed. We included 271 patients with a duration of diabetes greater than 15 years. Polymerase chain reaction-restriction fragment length polymorphism was used to analyze RANTES polymorphisms, identifying genotypes as GG, AG, or AA. Obesity was defined using the body mass index with a cutoff value of 25 kg/m2. Both microvascular (retinopathy and nephropathy) and macrovascular (coronary artery disease and cerebrovascular disease) complications were evaluated. Results: The duration of T2D and hemoglobin A1c values at enrollment were 24.4 ± 5.0 years and 7.8 ± 1.6%, respectively, in the non-obese group, and 25.4 ± 6.1 years and 7.7 ± 1.7%, respectively, in the obese group. The prevalence of microvascular complications was significantly higher in the obese group compared with that in the non-obese group (83.5% vs. 72.0%, p = 0.039). Compared to the non-obese group, the obese group showed a higher proportion of the patients with AA or AG genotypes (64.3% vs. 84.5%, p = 0.001). Conclusions: The A allele of the RANTES gene is associated with obesity and may affect diabetic microvascular complications in patients with T2D for over 15 years.
中文翻译：
RANTES 59029A/G 与 15 年以上韩国 2 型糖尿病患者的糖尿病编辑相关的多态性
背景：已知 RANTES 基因的多态性与几种与胰岛素抵抗有关的疾病有关。在本研究中，我们调查了患有 2 型糖尿病 (T2D) 超过 15 年的韩国患者的 RANTES 59029A/G 多态性与肥胖相关的糖尿病并发症患病率之间的关联。方法：进行了一项单中心、回顾性病例对照研究。我们纳入了 271 名糖尿病病程超过 15 年的患者。聚合酶链反应限制性片段长度多态性用于分析 RANTES 多态性，将基因型鉴定为 GG、AG 或 AA。肥胖是使用体重指数定义的，截止值为 25 kg/m 2. 评估了微血管（视网膜病变和肾病）和大血管（冠状动脉疾病和脑血管疾病）并发症。结果：在非肥胖组中，T2D 和血红蛋白 A1c 值的持续时间分别为 24.4 ± 5.0 年和 7.8 ± 1.6%，在肥胖组中分别为 25.4 ± 6.1 年和 7.7 ± 1.7%。肥胖组微血管并发症的发生率显着高于非肥胖组（83.5% vs. 72.0%，p = 0.039）。与非肥胖组相比，肥胖组具有 AA 或 AG 基因型的患者比例更高（64.3% vs. 84.5%，p= 0.001)。结论：RANTES 基因的 A 等位基因与肥胖相关，并可能影响 15 年以上 T2D 患者的糖尿病微血管并发症。
更新日期：2021-09-19
中文翻译：
RANTES 59029A/G 与 15 年以上韩国 2 型糖尿病患者的糖尿病编辑相关的多态性
背景：已知 RANTES 基因的多态性与几种与胰岛素抵抗有关的疾病有关。在本研究中，我们调查了患有 2 型糖尿病 (T2D) 超过 15 年的韩国患者的 RANTES 59029A/G 多态性与肥胖相关的糖尿病并发症患病率之间的关联。方法：进行了一项单中心、回顾性病例对照研究。我们纳入了 271 名糖尿病病程超过 15 年的患者。聚合酶链反应限制性片段长度多态性用于分析 RANTES 多态性，将基因型鉴定为 GG、AG 或 AA。肥胖是使用体重指数定义的，截止值为 25 kg/m 2. 评估了微血管（视网膜病变和肾病）和大血管（冠状动脉疾病和脑血管疾病）并发症。结果：在非肥胖组中，T2D 和血红蛋白 A1c 值的持续时间分别为 24.4 ± 5.0 年和 7.8 ± 1.6%，在肥胖组中分别为 25.4 ± 6.1 年和 7.7 ± 1.7%。肥胖组微血管并发症的发生率显着高于非肥胖组（83.5% vs. 72.0%，p = 0.039）。与非肥胖组相比，肥胖组具有 AA 或 AG 基因型的患者比例更高（64.3% vs. 84.5%，p= 0.001)。结论：RANTES 基因的 A 等位基因与肥胖相关，并可能影响 15 年以上 T2D 患者的糖尿病微血管并发症。
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