Since ancient times, animal models have provided fundamental information in medical knowledge. This also applies for discoveries in the field of inherited peripheral neuropathies (IPNs), where they have been instrumental for our understanding of nerve development, pathogenesis of neuropathy, molecules and pathways involved and to design potential therapies. In this review, we briefly describe how animal models have been used in ancient medicine until the use of rodents as the prevalent model in present times. We then travel along different examples of how rodents have been used to improve our understanding of IPNs. We do not intend to describe all discoveries and animal models developed for IPNs, but just to touch on a few arbitrary and paradigmatic examples, taken from our direct experience or from literature. The idea is to show how strategies have been developed to finally arrive to possible treatments for IPNs.

中文翻译：

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动物模型作为设计 CMT 样遗传性神经病治疗策略的工具

自古以来，动物模型就提供了医学知识的基本信息。这也适用于遗传性周围神经病 (IPN) 领域的发现，它们有助于我们了解神经发育、神经病的发病机制、所涉及的分子和通路以及设计潜在的治疗方法。在这篇综述中，我们简要描述了动物模型是如何在古代医学中使用的，直到现在使用啮齿动物作为流行模型。然后，我们将介绍如何使用啮齿动物来提高我们对 IPN 的理解的不同示例。我们不打算描述为 IPN 开发的所有发现和动物模型，而只是从我们的直接经验或文献中选取一些任意和典型的例子。