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The protective effects of 17-β estradiol and SIRT1 against cardiac hypertrophy: a review
Heart Failure Reviews ( IF 4.6 ) Pub Date : 2021-09-18 , DOI: 10.1007/s10741-021-10171-0
Zahra Hajializadeh 1 , Mohammad Khaksari 2
Affiliation  

One of the major causes of morbidity and mortality worldwide is cardiac hypertrophy (CH), which leads to heart failure. Sex differences in CH can be caused by sex hormones or their receptors. The incidence of CH increases in postmenopausal women due to the decrease in female sex hormone 17-β estradiol (E2) during menopause. E2 and its receptors inhibit CH in humans and animal models. Silent information regulator 1 (SIRT1) is a NAD+-dependent HDAC (histone deacetylase) and plays a major role in biological processes, such as inflammation, apoptosis, and oxidative stress responses. Probably SIRT1 because of these effects, is one of the main suppressors of CH and has a cardioprotective effect. On the other hand, estrogen and its agonists are highly efficient in modulating SIRT1 expression. In the present study, we review the protective effects of E2 and SIRT1 against CH.



中文翻译:

17-β雌二醇和SIRT1对心脏肥大的保护作用:综述

全世界发病率和死亡率的主要原因之一是导致心力衰竭的心脏肥大 (CH)。CH 的性别差异可能是由性激素或其受体引起的。由于绝经期间女性性激素 17-β 雌二醇 (E2) 的减少,绝经后女性的 CH 发病率增加。E2 及其受体在人和动物模型中抑制 CH。静音信息调节器 1 (SIRT1) 是 NAD +依赖性 HDAC(组蛋白脱乙酰酶),在炎症、细胞凋亡和氧化应激反应等生物过程中发挥重要作用。由于这些作用,SIRT1 可能是 CH 的主要抑制因子之一,并具有心脏保护作用。另一方面,雌激素及其激动剂在调节 SIRT1 表达方面非常有效。在本研究中,我们回顾了 E2 和 SIRT1 对 CH 的保护作用。

更新日期:2021-09-19
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