Background

The potential role of HIST1H2BN in prostate cancer remains unclear.

Objective

To evaluate the carcinogenic role of HIST1H2BN in prostate cancer.

Methods

The expression of HIST1H2BN in prostate cancer was analyzed using TCGA database and clinical samples. The roles and mechanisms of HIST1H2BN were investigated in DU145 and PC3 cells.

Results

HIST1H2BN was significantly upregulated in prostate cancer. HIST1H2BN knockdown inhibited cell proliferation, migration and EMT phenotype in prostate cancer cells. Downregulating HIST1H2BN diminished the expression and binding activity of NF-κB p65, then influenced the expression of MMP2 and MMP9.

Conclusion 

This is the first study to elaborate a HIST1H2BN-NF-κB-EMT regulatory axis in oncogenesis, indicating that HIST1H2BN might be potential therapeutic target for prostate cancer.

中文翻译：

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HIST1H2BN通过NF-κB信号通路诱导前列腺癌细胞增殖和EMT表型

背景

HIST1H2BN 在前列腺癌中的潜在作用仍不清楚。

客观的

评估 HIST1H2BN 在前列腺癌中的致癌作用。

方法

使用 TCGA 数据库和临床样本分析 HIST1H2BN 在前列腺癌中的表达。在 DU145 和 PC3 细胞中研究了 HIST1H2BN 的作用和机制。

结果

HIST1H2BN 在前列腺癌中显着上调。HIST1H2BN 敲低抑制前列腺癌细胞中的细胞增殖、迁移和 EMT 表型。下调 HIST1H2BN 会降低 NF-κB p65 的表达和结合活性，然后影响 MMP2 和 MMP9 的表达。

结论 

这是第一项详细阐述 HIST1H2BN-NF-κB-EMT 调控轴在肿瘤发生中的研究，表明 HIST1H2BN 可能是前列腺癌的潜在治疗靶点。