Retinoids are not linked to risk of multiple sclerosis: A Danish nationwide cohort study,European Journal of Neurology

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Retinoids are not linked to risk of multiple sclerosis: A Danish nationwide cohort study
European Journal of Neurology ( IF 5.1 ) Pub Date : 2021-09-18 , DOI: 10.1111/ene.15116
Filipe Cortes-Figueiredo _{1,

2,

3} , Nete Munk Nielsen _{4,

5} , Egon Stenager _{6,

7} , Friedemann Paul _{2,

8} , Jesper Hallas ₃ , Kasper Bruun Kristensen ₃

Affiliation

VMorais Lab - Mitochondria Biology and Neurodegeneration, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Focused Research Unit in Neurology, Department of Neurology, Hospital of Southern Jutland, University of Southern Denmark, Denmark.
MS-clinic of Southern Jutland (Sønderborg, Esbjerg, Kolding), Department of Neurology, Hospital of Southern Jutland, Sønderborg, Denmark.
Department of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany.

Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system with an undetermined etiology. Retinoids may have immunomodulatory effects that favorably influence MS progression. We aimed to explore the yet unknown relationship between exposure to retinoids and the risk of acquiring MS.

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